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Main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the Copenhagen Male Study

Little knowledge exists about the role of cardiorespiratory fitness (CRF) or its interaction with excess adiposity determined by body mass index (BMI) in cancer prevention. A total of 5,128 middle-aged men, without a history of cancer at baseline in 1970–71, were examined for subsequent incidence an...

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Autores principales: Nunez, Carlos, Clausen, Johan, Jensen, Magnus Thorsten, Holtermann, Andreas, Gyntelberg, Finn, Bauman, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078972/
https://www.ncbi.nlm.nih.gov/pubmed/30082878
http://dx.doi.org/10.1038/s41598-018-30280-5
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author Nunez, Carlos
Clausen, Johan
Jensen, Magnus Thorsten
Holtermann, Andreas
Gyntelberg, Finn
Bauman, Adrian
author_facet Nunez, Carlos
Clausen, Johan
Jensen, Magnus Thorsten
Holtermann, Andreas
Gyntelberg, Finn
Bauman, Adrian
author_sort Nunez, Carlos
collection PubMed
description Little knowledge exists about the role of cardiorespiratory fitness (CRF) or its interaction with excess adiposity determined by body mass index (BMI) in cancer prevention. A total of 5,128 middle-aged men, without a history of cancer at baseline in 1970–71, were examined for subsequent incidence and mortality of several cancer types. Participants’ data were linked with cancer registration and mortality data to March 2017. During 47 years of follow-up, a total of 1,920 incident cases and 1,638 cancer-related deaths were ascertained. BMI, particularly obesity, was associated with (i) incidence and (ii) mortality from respiratory/thoracic cancers; and (iii) all cancer-cause mortality. The respective adjusted hazard ratios (HRs) were: (i) 0.51 (95%CI:0.32–0.79), (ii) 0.48 (95%CI:0.30–0.75) and (iii) 0.73 (95%CI:0.59–0.89) when compared obese men (BMI ≥30 kg/m(2)) to men with healthy-BMI (<25 kg/m(2)). Increasing CRF was inversely associated with incidence and mortality of respiratory/thoracic cancers, HRs 0.78 (95%CI:0.67–0.90) and 0.73 (95%CI:0.63–0.84) respectively; and all cancer-cause incidence 0.92 (95%CI:0.86–0.98) and mortality 0.85 (95%CI:0.79–0.91). Physical activity (PA) was not associated with most outcomes. We found no evidence of interactions between CRF or PA and BMI on cancer risk. This evidence suggests that midlife CRF is associated with lowered risk of cancer incidence and mortality with no evidence of cancer risk modification by BMI.
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spelling pubmed-60789722018-08-09 Main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the Copenhagen Male Study Nunez, Carlos Clausen, Johan Jensen, Magnus Thorsten Holtermann, Andreas Gyntelberg, Finn Bauman, Adrian Sci Rep Article Little knowledge exists about the role of cardiorespiratory fitness (CRF) or its interaction with excess adiposity determined by body mass index (BMI) in cancer prevention. A total of 5,128 middle-aged men, without a history of cancer at baseline in 1970–71, were examined for subsequent incidence and mortality of several cancer types. Participants’ data were linked with cancer registration and mortality data to March 2017. During 47 years of follow-up, a total of 1,920 incident cases and 1,638 cancer-related deaths were ascertained. BMI, particularly obesity, was associated with (i) incidence and (ii) mortality from respiratory/thoracic cancers; and (iii) all cancer-cause mortality. The respective adjusted hazard ratios (HRs) were: (i) 0.51 (95%CI:0.32–0.79), (ii) 0.48 (95%CI:0.30–0.75) and (iii) 0.73 (95%CI:0.59–0.89) when compared obese men (BMI ≥30 kg/m(2)) to men with healthy-BMI (<25 kg/m(2)). Increasing CRF was inversely associated with incidence and mortality of respiratory/thoracic cancers, HRs 0.78 (95%CI:0.67–0.90) and 0.73 (95%CI:0.63–0.84) respectively; and all cancer-cause incidence 0.92 (95%CI:0.86–0.98) and mortality 0.85 (95%CI:0.79–0.91). Physical activity (PA) was not associated with most outcomes. We found no evidence of interactions between CRF or PA and BMI on cancer risk. This evidence suggests that midlife CRF is associated with lowered risk of cancer incidence and mortality with no evidence of cancer risk modification by BMI. Nature Publishing Group UK 2018-08-06 /pmc/articles/PMC6078972/ /pubmed/30082878 http://dx.doi.org/10.1038/s41598-018-30280-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Nunez, Carlos
Clausen, Johan
Jensen, Magnus Thorsten
Holtermann, Andreas
Gyntelberg, Finn
Bauman, Adrian
Main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the Copenhagen Male Study
title Main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the Copenhagen Male Study
title_full Main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the Copenhagen Male Study
title_fullStr Main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the Copenhagen Male Study
title_full_unstemmed Main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the Copenhagen Male Study
title_short Main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the Copenhagen Male Study
title_sort main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the copenhagen male study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078972/
https://www.ncbi.nlm.nih.gov/pubmed/30082878
http://dx.doi.org/10.1038/s41598-018-30280-5
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