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Molecular characterization of echovirus 12 strains isolated from healthy children in China

Human echovirus 12 (E-12) belongs to the enterovirus B species. To date, only one full-length genome sequence of E-12 (prototype strain Travis) is available in the GenBank database. This study determined the complete sequence of three E-12 strains, which were isolated from the stools of three health...

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Detalles Bibliográficos
Autores principales: Liu, Hongbo, Zhang, Jie, Zhao, Yilin, Zhang, Haihao, Lin, Keqin, Sun, Hao, Huang, Xiaoqin, Yang, Zhaoqing, Ma, Shaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078983/
https://www.ncbi.nlm.nih.gov/pubmed/30082917
http://dx.doi.org/10.1038/s41598-018-30250-x
Descripción
Sumario:Human echovirus 12 (E-12) belongs to the enterovirus B species. To date, only one full-length genome sequence of E-12 (prototype strain Travis) is available in the GenBank database. This study determined the complete sequence of three E-12 strains, which were isolated from the stools of three healthy children in Yunnan, China, in 2013. We revealed that the three Yunnan E-12 strains had only 80.8–80.9% nucleotide identity and 96.4–96.8% amino acid identity with the Travis strain based on pairwise comparisons of the complete genome nucleotide and amino acid sequences. The three Yunnan strains shared 99.7% nucleotide identity and 99.1–99.5% amino acid similarity. Phylogenetic and similarity plot analyses showed that intertypic recombination occurred in the non-structural regions of the three Yunnan E-12 strains. This is the first report of the complete genome sequence of E-12 in China and it enriches the complete genome sequences of E-12 in the GenBank database.