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Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area

The integration and utilization of feedback in order to determine which decision strategy to use in different contexts is the core of executive function. The anterior cingulate cortex (ACC) is central to these processes but how feedback is made available to the ACC is unclear. To address this questi...

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Autores principales: Elston, Thomas W., Kalhan, Shivam, Bilkey, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079061/
https://www.ncbi.nlm.nih.gov/pubmed/30082775
http://dx.doi.org/10.1038/s41598-018-30203-4
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author Elston, Thomas W.
Kalhan, Shivam
Bilkey, David K.
author_facet Elston, Thomas W.
Kalhan, Shivam
Bilkey, David K.
author_sort Elston, Thomas W.
collection PubMed
description The integration and utilization of feedback in order to determine which decision strategy to use in different contexts is the core of executive function. The anterior cingulate cortex (ACC) is central to these processes but how feedback is made available to the ACC is unclear. To address this question, we trained rats with implants in the ACC and the ventral tegmental area (VTA), a dopaminergic brain region implicated in feedback processing, in a spatial decision reversal task with rule switching occurring approximately every 12 trials. Following a rule switch, the rats had to shift and sustain responses to the alternative side in order to obtain reward. Partial directed coherence (PDC) models of signal directionality between the ACC and VTA indicated that VTA → ACC communication (near 4 Hz) increased immediately prior to incorrect choices and during post-error decisions. This increase did not occur during correct choices. These data indicate that the VTA provides a feedback-driven, bottom-up modulating signal to the ACC which may be involved in assessing, and correcting for, decision conflict.
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spelling pubmed-60790612018-08-09 Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area Elston, Thomas W. Kalhan, Shivam Bilkey, David K. Sci Rep Article The integration and utilization of feedback in order to determine which decision strategy to use in different contexts is the core of executive function. The anterior cingulate cortex (ACC) is central to these processes but how feedback is made available to the ACC is unclear. To address this question, we trained rats with implants in the ACC and the ventral tegmental area (VTA), a dopaminergic brain region implicated in feedback processing, in a spatial decision reversal task with rule switching occurring approximately every 12 trials. Following a rule switch, the rats had to shift and sustain responses to the alternative side in order to obtain reward. Partial directed coherence (PDC) models of signal directionality between the ACC and VTA indicated that VTA → ACC communication (near 4 Hz) increased immediately prior to incorrect choices and during post-error decisions. This increase did not occur during correct choices. These data indicate that the VTA provides a feedback-driven, bottom-up modulating signal to the ACC which may be involved in assessing, and correcting for, decision conflict. Nature Publishing Group UK 2018-08-06 /pmc/articles/PMC6079061/ /pubmed/30082775 http://dx.doi.org/10.1038/s41598-018-30203-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Elston, Thomas W.
Kalhan, Shivam
Bilkey, David K.
Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title_full Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title_fullStr Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title_full_unstemmed Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title_short Conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
title_sort conflict and adaptation signals in the anterior cingulate cortex and ventral tegmental area
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079061/
https://www.ncbi.nlm.nih.gov/pubmed/30082775
http://dx.doi.org/10.1038/s41598-018-30203-4
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