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Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells (DC), resulting in enhanced MHC-II-dependent antigen presentation and CD4(+) T-cell activat...

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Detalles Bibliográficos
Autores principales:	Bonacina, Fabrizia, Coe, David, Wang, Guosu, Longhi, Maria P., Baragetti, Andrea, Moregola, Annalisa, Garlaschelli, Katia, Uboldi, Patrizia, Pellegatta, Fabio, Grigore, Liliana, Da Dalt, Lorenzo, Annoni, Andrea, Gregori, Silvia, Xiao, Qingzhong, Caruso, Donatella, Mitro, Nico, Catapano, Alberico L., Marelli-Berg, Federica M., Norata, Giuseppe D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079066/ https://www.ncbi.nlm.nih.gov/pubmed/30082772 http://dx.doi.org/10.1038/s41467-018-05322-1

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