Nano-sized Al(2)O(3) particle-induced autophagy reduces osteolysis in aseptic loosening of total hip arthroplasty by negative feedback regulation of RANKL expression in fibroblasts

Aseptic loosening is mainly caused by wear debris generated by friction that can increase the expression of receptor activation of nuclear factor (NF)-κB (RANKL). RANKL has been shown to support the differentiation and maturation of osteoclasts. Although autophagy is a key metabolic pathway for main...

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Detalles Bibliográficos
Autores principales: Li, De, Wang, Chenglong, Li, Zhuokai, Wang, Hui, He, Jiye, Zhu, Junfeng, Zhang, Yuehui, Shen, Chao, Xiao, Fei, Gao, Yuan, Zhang, Xiang, Li, Yang, Wang, Peng, Peng, Jianping, Cai, Guiquan, Zuo, Bin, Yang, Yuehua, Shen, Yun, Song, Weidong, Zhang, Xiaoling, Shen, Lei, Chen, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079072/
https://www.ncbi.nlm.nih.gov/pubmed/30082761
http://dx.doi.org/10.1038/s41419-018-0862-9

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