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In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator

mGlu5 receptor-mediated polyphosphoinositide (PI) hydrolysis is classically measured by determining the amount of radioactivity incorporated in inositolmonophosphate (InsP) after labeling of membrane phospholipids with radioactive inositol. Although this method is historically linked to the study of...

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Detalles Bibliográficos
Autores principales:	Zuena, Anna R., Iacovelli, Luisa, Orlando, Rosamaria, Di Menna, Luisa, Casolini, Paola, Alemà, Giovanni Sebastiano, Di Cicco, Gabriele, Battaglia, Giuseppe, Nicoletti, Ferdinando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079191/ https://www.ncbi.nlm.nih.gov/pubmed/30108503 http://dx.doi.org/10.3389/fphar.2018.00804

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