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Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans

Transcranial alternating current stimulation (tACS) is a noninvasive neurophysiological technique that can entrain brain oscillations. Only few studies have investigated the effects of tACS on voluntary movements. We aimed to verify whether tACS, delivered over M1 at beta and gamma frequencies, has...

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Autores principales: Guerra, Andrea, Bologna, Matteo, Paparella, Giulia, Suppa, Antonio, Colella, Donato, Di Lazzaro, Vincenzo, Brown, Peter, Berardelli, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079362/
https://www.ncbi.nlm.nih.gov/pubmed/30123248
http://dx.doi.org/10.1155/2018/4593095
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author Guerra, Andrea
Bologna, Matteo
Paparella, Giulia
Suppa, Antonio
Colella, Donato
Di Lazzaro, Vincenzo
Brown, Peter
Berardelli, Alfredo
author_facet Guerra, Andrea
Bologna, Matteo
Paparella, Giulia
Suppa, Antonio
Colella, Donato
Di Lazzaro, Vincenzo
Brown, Peter
Berardelli, Alfredo
author_sort Guerra, Andrea
collection PubMed
description Transcranial alternating current stimulation (tACS) is a noninvasive neurophysiological technique that can entrain brain oscillations. Only few studies have investigated the effects of tACS on voluntary movements. We aimed to verify whether tACS, delivered over M1 at beta and gamma frequencies, has any effect on repetitive finger tapping as assessed by means of kinematic analysis. Eighteen healthy subjects were enrolled. Objective measurements of repetitive finger tapping were obtained by using a motion analysis system. M1 excitability was assessed by using single-pulse TMS and measuring the amplitude of motor-evoked potentials (MEPs). Movement kinematic measures and MEPs were collected during beta, gamma, and sham tACS and when the stimulation was off. Beta tACS led to an amplitude decrement (i.e., progressive reduction in amplitude) across the first ten movements of the motor sequence while gamma tACS had the opposite effect. The results did not reveal any significant effect of tACS on other movement parameters, nor any changes in MEPs. These findings demonstrate that tACS modulates finger tapping in a frequency-dependent manner with no concurrent changes in corticospinal excitability. The results suggest that cortical beta and gamma oscillations are involved in the motor control of repetitive finger movements.
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spelling pubmed-60793622018-08-19 Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans Guerra, Andrea Bologna, Matteo Paparella, Giulia Suppa, Antonio Colella, Donato Di Lazzaro, Vincenzo Brown, Peter Berardelli, Alfredo Neural Plast Research Article Transcranial alternating current stimulation (tACS) is a noninvasive neurophysiological technique that can entrain brain oscillations. Only few studies have investigated the effects of tACS on voluntary movements. We aimed to verify whether tACS, delivered over M1 at beta and gamma frequencies, has any effect on repetitive finger tapping as assessed by means of kinematic analysis. Eighteen healthy subjects were enrolled. Objective measurements of repetitive finger tapping were obtained by using a motion analysis system. M1 excitability was assessed by using single-pulse TMS and measuring the amplitude of motor-evoked potentials (MEPs). Movement kinematic measures and MEPs were collected during beta, gamma, and sham tACS and when the stimulation was off. Beta tACS led to an amplitude decrement (i.e., progressive reduction in amplitude) across the first ten movements of the motor sequence while gamma tACS had the opposite effect. The results did not reveal any significant effect of tACS on other movement parameters, nor any changes in MEPs. These findings demonstrate that tACS modulates finger tapping in a frequency-dependent manner with no concurrent changes in corticospinal excitability. The results suggest that cortical beta and gamma oscillations are involved in the motor control of repetitive finger movements. Hindawi 2018-07-08 /pmc/articles/PMC6079362/ /pubmed/30123248 http://dx.doi.org/10.1155/2018/4593095 Text en Copyright © 2018 Andrea Guerra et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Guerra, Andrea
Bologna, Matteo
Paparella, Giulia
Suppa, Antonio
Colella, Donato
Di Lazzaro, Vincenzo
Brown, Peter
Berardelli, Alfredo
Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans
title Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans
title_full Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans
title_fullStr Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans
title_full_unstemmed Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans
title_short Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans
title_sort effects of transcranial alternating current stimulation on repetitive finger movements in healthy humans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079362/
https://www.ncbi.nlm.nih.gov/pubmed/30123248
http://dx.doi.org/10.1155/2018/4593095
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