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Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear

Myo3a is expressed in cochlear hair cells and retinal cells and is responsible for human recessive hereditary nonsyndromic deafness (DFNB30). To investigate the mechanism of DFNB30-type deafness, we established a mouse model of Myo3a kinase domain Y137C mutation by using CRISPR/Cas9 system. No diffe...

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Detalles Bibliográficos
Autores principales:	Li, Peipei, Wen, Zongzhuang, Zhang, Guangkai, Zhang, Aizhen, Fu, Xiaolong, Gao, Jiangang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079384/ https://www.ncbi.nlm.nih.gov/pubmed/30123247 http://dx.doi.org/10.1155/2018/4372913

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