Cargando…

Inhibition of Proteasome Activity Upregulates IL-6 Expression in RPE Cells through the Activation of P38 MAPKs

PURPOSE: As far as we know, during the development of age-related macular degeneration (AMD), the activity of proteasome in retinal pigment epithelium cells (RPE) gradually decreases. And a lot of research has shown that age-related macular degeneration is closely related to inflammation and autoimm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Tingyu, Gao, Shasha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079444/ https://www.ncbi.nlm.nih.gov/pubmed/30116631 http://dx.doi.org/10.1155/2018/5392432

Ejemplares similares

Attenuation of High Glucose-Induced Damage in RPE Cells through p38 MAPK Signaling Pathway Inhibition
por: Maugeri, Grazia, et al.
Publicado: (2021)

Sulforaphane Upregulates Cultured Mouse Astrocytic Aquaporin-4 Expression through p38 MAPK Pathway
por: Yang, Canhong, et al.
Publicado: (2022)

Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity
por: Barker, Katie H., et al.
Publicado: (2023)

Inhibition of LPS-Induced Activation of Coagulation by p38 MAPK Inhibitor
por: Koch, Lutz, et al.
Publicado: (2012)

Hemin inhibits NO production by IL-1β-stimulated human astrocytes through induction of heme oxygenase-1 and reduction of p38 MAPK activation
por: Sheng, Wen S, et al.
Publicado: (2010)

Hemokinin-1 Gene Expression Is Upregulated in Microglia Activated by Lipopolysaccharide through NF-κB and p38 MAPK Signaling Pathways
por: Sakai, Atsushi, et al.
Publicado: (2012)

Tripterygium wilfordii Glycosides Upregulate the New Anti-Inflammatory Cytokine IL-37 through ERK1/2 and p38 MAPK Signal Pathways
por: Wang, Sen, et al.
Publicado: (2017)

p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy
por: Escós, Alejandra, et al.
Publicado: (2016)

Tangeretin Inhibition of High-Glucose-Induced IL-1β, IL-6, TGF-β1, and VEGF Expression in Human RPE Cells
por: Qin, Dong, et al.
Publicado: (2020)

Celecoxib Inhibits the Lytic Activation of Kaposi’s Sarcoma-Associated Herpesvirus through Down-Regulation of RTA Expression by Inhibiting the Activation of p38 MAPK
por: Chen, Jungang, et al.
Publicado: (2015)

Inhibition of HDAC6 alleviating lipopolysaccharide-induced p38MAPK phosphorylation and neuroinflammation in mice
por: Song, Yuanjian, et al.
Publicado: (2019)

Serum amyloid A inhibits astrocyte migration via activating p38 MAPK
por: Lin, Aihua, et al.
Publicado: (2020)

Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-κB
por: Huang, Xia, et al.
Publicado: (2017)

Anisomycin Activates Utrophin Upregulation Through a p38 Signaling Pathway
por: Hadwen, Jeremiah, et al.
Publicado: (2018)

Activation of p38 MAPK participates in the sulbactam-induced cerebral ischemic tolerance mediated by glial glutamate transporter-1 upregulation in rats
por: Xian, Xiao-Hui, et al.
Publicado: (2020)

Bridelia ferruginea Produces Antineuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling
por: Olajide, Olumayokun A., et al.
Publicado: (2012)

Human Ribosomal Proteins RPeL27, RPeL43, and RPeL41 Are Upregulated in Nasopharyngeal Carcinoma Cell Lines
por: Sim, Edmund Ui-Hang, et al.
Publicado: (2016)

CCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis
por: Sun, Yue, et al.
Publicado: (2017)

Hydrogen Peroxide Induce Human Cytomegalovirus Replication through the Activation of p38-MAPK Signaling Pathway
por: Xiao, Jun, et al.
Publicado: (2015)

The influence of JNK and P38 MAPK inhibition on IL-12P40 and IL-23 production depending on IL12B promoter polymorphism
por: Dobreva, Zlatka Georgieva, et al.
Publicado: (2009)

Virus-induced p38 MAPK activation facilitates viral infection
por: Cheng, Yuting, et al.
Publicado: (2020)

IL-23 Inhibits Trophoblast Proliferation, Migration, and EMT via Activating p38 MAPK Signaling Pathway to Promote Recurrent Spontaneous Abortion
por: He, Shan, et al.
Publicado: (2022)

TIRAP-mediated activation of p38 MAPK in inflammatory signaling
por: Rajpoot, Sajjan, et al.
Publicado: (2022)

TNF-α mediates choroidal neovascularization by upregulating VEGF expression in RPE through ROS-dependent β-catenin activation
por: Wang, Haibo, et al.
Publicado: (2016)

Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model
por: Yu, Chao, et al.
Publicado: (2020)

Mulberry extract upregulates cholesterol efflux and inhibits p38 MAPK‐NLRP3‐mediated inflammation in foam cells
por: Liu, Yuting, et al.
Publicado: (2023)

The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
por: Arafa, El-Shaimaa A., et al.
Publicado: (2021)

p38 MAPK Facilitates Crosstalk Between Endoplasmic Reticulum Stress and IL-6 Release in the Intervertebral Disc
por: Krupkova, Olga, et al.
Publicado: (2018)

Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells
por: Wu, Yuchao, et al.
Publicado: (2022)

N-Hydroxycinnamide Derivatives of Osthole Ameliorate Hyperglycemia through Activation of AMPK and p38 MAPK
por: Lee, Wei-Hwa, et al.
Publicado: (2015)

Heme Oxygenase-1 Induction in Human BeWo Trophoblast Cells Decreases Toxoplasma gondii Proliferation in Association With the Upregulation of p38 MAPK Phosphorylation and IL-6 Production
por: Almeida, Marcos Paulo Oliveira, et al.
Publicado: (2021)

Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation
por: Qin, Qingyu, et al.
Publicado: (2010)

LZAP Inhibits p38 MAPK (p38) Phosphorylation and Activity by Facilitating p38 Association with the Wild-Type p53 Induced Phosphatase 1 (WIP1)
por: An, Hanbing, et al.
Publicado: (2011)

Penehyclidine hydrochloride suppressed peripheral nerve injury-induced neuropathic pain by inhibiting microglial MAPK/p-p38/IL-1β pathway activation
por: Zheng, Shao-Hua, et al.
Publicado: (2019)

Proteasome Inhibitors Activate Autophagy Involving Inhibition of PI3K-Akt-mTOR Pathway as an Anti-Oxidation Defense in Human RPE Cells
por: Tang, Bingrong, et al.
Publicado: (2014)

Ginaton injection alleviates cisplatin-induced renal interstitial fibrosis in rats via inhibition of apoptosis through regulation of the p38MAPK/TGF-β1 and p38MAPK/HIF-1α pathways
por: Liang, Taolin, et al.
Publicado: (2021)

Endothelial lipase is upregulated by interleukin-6 partly via the p38 MAPK and p65 NF-κB signaling pathways
por: Yue, Xin, et al.
Publicado: (2016)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

TES inhibits colorectal cancer progression through activation of p38
por: Li, Huili, et al.
Publicado: (2016)

Activation of p38MAPK Contributes to Expanded Polyglutamine-Induced Cytotoxicity
por: Tsirigotis, Maria, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_5n9cji2vdote5s3guoqojsqihn