Association of HLA-B(∗)38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients

BACKGROUND: HLA-B(∗)38:02 has been shown to be associated with antithyroid drug-induced agranulocytosis in Asian patients. METHODS: HLA-B(∗)38:02 was analyzed by sequence-based typing in 21 patients who developed antithyroid drug-induced agranulocytosis and in 81 controls. RESULTS: Frequency of HLA-...

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Detalles Bibliográficos
Autores principales: Thao, Mai Phuong, Tuan, Pham Vo Anh, Linh, Le Gia Hoang, Van Hoang, Lam, Hen, Phan Huu, Hoa, Le Tuyet, Vu, Hoang Anh, Minh, Do Duc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079452/
https://www.ncbi.nlm.nih.gov/pubmed/30123266
http://dx.doi.org/10.1155/2018/7965346
Descripción
Sumario:BACKGROUND: HLA-B(∗)38:02 has been shown to be associated with antithyroid drug-induced agranulocytosis in Asian patients. METHODS: HLA-B(∗)38:02 was analyzed by sequence-based typing in 21 patients who developed antithyroid drug-induced agranulocytosis and in 81 controls. RESULTS: Frequency of HLA-B(∗)38:02 was 52.4% in agranulocytosis patients compared to 3.7% in controls (OR = 28.6, 95% CI = 6.8–120.2). CONCLUSIONS: HLA-B(∗)38:02 is a significant risk factor for agranulocytosis in Kinh Vietnamese patients treated with antithyroid drug.

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