Association of HLA-B(∗)38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients

BACKGROUND: HLA-B(∗)38:02 has been shown to be associated with antithyroid drug-induced agranulocytosis in Asian patients. METHODS: HLA-B(∗)38:02 was analyzed by sequence-based typing in 21 patients who developed antithyroid drug-induced agranulocytosis and in 81 controls. RESULTS: Frequency of HLA-...

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Autores principales: Thao, Mai Phuong, Tuan, Pham Vo Anh, Linh, Le Gia Hoang, Van Hoang, Lam, Hen, Phan Huu, Hoa, Le Tuyet, Vu, Hoang Anh, Minh, Do Duc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079452/
https://www.ncbi.nlm.nih.gov/pubmed/30123266
http://dx.doi.org/10.1155/2018/7965346
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author Thao, Mai Phuong
Tuan, Pham Vo Anh
Linh, Le Gia Hoang
Van Hoang, Lam
Hen, Phan Huu
Hoa, Le Tuyet
Vu, Hoang Anh
Minh, Do Duc
author_facet Thao, Mai Phuong
Tuan, Pham Vo Anh
Linh, Le Gia Hoang
Van Hoang, Lam
Hen, Phan Huu
Hoa, Le Tuyet
Vu, Hoang Anh
Minh, Do Duc
author_sort Thao, Mai Phuong
collection PubMed
description BACKGROUND: HLA-B(∗)38:02 has been shown to be associated with antithyroid drug-induced agranulocytosis in Asian patients. METHODS: HLA-B(∗)38:02 was analyzed by sequence-based typing in 21 patients who developed antithyroid drug-induced agranulocytosis and in 81 controls. RESULTS: Frequency of HLA-B(∗)38:02 was 52.4% in agranulocytosis patients compared to 3.7% in controls (OR = 28.6, 95% CI = 6.8–120.2). CONCLUSIONS: HLA-B(∗)38:02 is a significant risk factor for agranulocytosis in Kinh Vietnamese patients treated with antithyroid drug.
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spelling pubmed-60794522018-08-19 Association of HLA-B(∗)38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients Thao, Mai Phuong Tuan, Pham Vo Anh Linh, Le Gia Hoang Van Hoang, Lam Hen, Phan Huu Hoa, Le Tuyet Vu, Hoang Anh Minh, Do Duc Int J Endocrinol Research Article BACKGROUND: HLA-B(∗)38:02 has been shown to be associated with antithyroid drug-induced agranulocytosis in Asian patients. METHODS: HLA-B(∗)38:02 was analyzed by sequence-based typing in 21 patients who developed antithyroid drug-induced agranulocytosis and in 81 controls. RESULTS: Frequency of HLA-B(∗)38:02 was 52.4% in agranulocytosis patients compared to 3.7% in controls (OR = 28.6, 95% CI = 6.8–120.2). CONCLUSIONS: HLA-B(∗)38:02 is a significant risk factor for agranulocytosis in Kinh Vietnamese patients treated with antithyroid drug. Hindawi 2018-07-05 /pmc/articles/PMC6079452/ /pubmed/30123266 http://dx.doi.org/10.1155/2018/7965346 Text en Copyright © 2018 Mai Phuong Thao et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Thao, Mai Phuong
Tuan, Pham Vo Anh
Linh, Le Gia Hoang
Van Hoang, Lam
Hen, Phan Huu
Hoa, Le Tuyet
Vu, Hoang Anh
Minh, Do Duc
Association of HLA-B(∗)38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients
title Association of HLA-B(∗)38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients
title_full Association of HLA-B(∗)38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients
title_fullStr Association of HLA-B(∗)38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients
title_full_unstemmed Association of HLA-B(∗)38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients
title_short Association of HLA-B(∗)38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients
title_sort association of hla-b(∗)38:02 with antithyroid drug-induced agranulocytosis in kinh vietnamese patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079452/
https://www.ncbi.nlm.nih.gov/pubmed/30123266
http://dx.doi.org/10.1155/2018/7965346
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