DPP-4 Inhibitor Sitagliptin Improves Cardiac Function and Glucose Homeostasis and Ameliorates β-Cell Dysfunction Together with Reducing S6K1 Activation and IRS-1 and IRS-2 Degradation in Obesity Female Mice

BACKGROUND: Chronic overnutrition leads to cardiac dysfunction and insulin (INS) resistance. Dipeptidyl peptidase-4 (DPP-4) improves glucose metabolism and insulin sensitivity in both human and animal models. In this study, we explored whether DPP-4 inhibitor sitagliptin (SIT) is involved in the pro...

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Detalles Bibliográficos
Autores principales: Qiao, Shigang, Mao, Guofang, Li, Hua, Ma, Zhimin, Hong, Lei, Zhang, Huiling, Wang, Chen, An, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079488/
https://www.ncbi.nlm.nih.gov/pubmed/30116740
http://dx.doi.org/10.1155/2018/3641516

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