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Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials
Gliomas are primary brain tumors presumably derived from glial cells. The WHO grade IV glioblastoma (GBM), characterized by rapid cell proliferation, easily recrudescent, high morbidity, and mortality, is the most common, devastating, and lethal gliomas. Molecular mechanisms underlying the pathogene...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079499/ https://www.ncbi.nlm.nih.gov/pubmed/30116729 http://dx.doi.org/10.1155/2018/2895958 |
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author | Zeng, Tao Li, Lei Zhou, Yan Gao, Liang |
author_facet | Zeng, Tao Li, Lei Zhou, Yan Gao, Liang |
author_sort | Zeng, Tao |
collection | PubMed |
description | Gliomas are primary brain tumors presumably derived from glial cells. The WHO grade IV glioblastoma (GBM), characterized by rapid cell proliferation, easily recrudescent, high morbidity, and mortality, is the most common, devastating, and lethal gliomas. Molecular mechanisms underlying the pathogenesis and progression of GBMs with potential diagnostic and therapeutic value have been explored industriously. With the advent of high-throughput technologies, numerous long noncoding RNAs (lncRNAs) aberrantly expressed in GBMs were discovered recently, some of them probably involved in GBM initiation, malignant progression, relapse and resistant to therapy, or showing diagnostic and prognostic value. In this review, we summarized the profile of lncRNAs that has been extensively investigated in glioma research, with a focus on their regulatory mechanisms. Then, their diagnostic, prognostic, and therapeutic implications were also discussed. |
format | Online Article Text |
id | pubmed-6079499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60794992018-08-16 Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials Zeng, Tao Li, Lei Zhou, Yan Gao, Liang Int J Genomics Review Article Gliomas are primary brain tumors presumably derived from glial cells. The WHO grade IV glioblastoma (GBM), characterized by rapid cell proliferation, easily recrudescent, high morbidity, and mortality, is the most common, devastating, and lethal gliomas. Molecular mechanisms underlying the pathogenesis and progression of GBMs with potential diagnostic and therapeutic value have been explored industriously. With the advent of high-throughput technologies, numerous long noncoding RNAs (lncRNAs) aberrantly expressed in GBMs were discovered recently, some of them probably involved in GBM initiation, malignant progression, relapse and resistant to therapy, or showing diagnostic and prognostic value. In this review, we summarized the profile of lncRNAs that has been extensively investigated in glioma research, with a focus on their regulatory mechanisms. Then, their diagnostic, prognostic, and therapeutic implications were also discussed. Hindawi 2018-07-12 /pmc/articles/PMC6079499/ /pubmed/30116729 http://dx.doi.org/10.1155/2018/2895958 Text en Copyright © 2018 Tao Zeng et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zeng, Tao Li, Lei Zhou, Yan Gao, Liang Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
title | Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
title_full | Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
title_fullStr | Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
title_full_unstemmed | Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
title_short | Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials |
title_sort | exploring long noncoding rnas in glioblastoma: regulatory mechanisms and clinical potentials |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079499/ https://www.ncbi.nlm.nih.gov/pubmed/30116729 http://dx.doi.org/10.1155/2018/2895958 |
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