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Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus

PURPOSE: To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. METHODS: One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, an...

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Autores principales: He, Fanglin, Zhao, Zhanlin, Liu, Yan, Lu, Linna, Fu, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079525/
https://www.ncbi.nlm.nih.gov/pubmed/30116624
http://dx.doi.org/10.1155/2018/1206808
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author He, Fanglin
Zhao, Zhanlin
Liu, Yan
Lu, Linna
Fu, Yao
author_facet He, Fanglin
Zhao, Zhanlin
Liu, Yan
Lu, Linna
Fu, Yao
author_sort He, Fanglin
collection PubMed
description PURPOSE: To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. METHODS: One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore). RESULTS: The noninvasive breakup time first (NIKBUT-1st) and noninvasive breakup time average (NIKBUT-avg) were significantly shorter in the over 10 years diabetic group compared with the control group (P=0.0056  and  P=0.010, resp.). Tear meniscus height (TMH) was significantly lower in the over 10 years diabetic group compared with the control group (P=0.0016) and the 5 years group (P=0.0061). We also found that more patients in the over 10 years diabetic group showed bulbar and limbal hyperemia compared with the control group (bulbar hyperemia: P=0.049; limbal hyperemia: P=0.026). The meiboscore in the over 10 years diabetic group was significantly higher compared with the other three groups (P < 0.05). Bulbar hyperemia showed a significant negative correlation with NIKBUT-1st in the over 10 years diabetic group (r=−0.35  and  P < 0.05). CONCLUSION: Ocular surface damage in long-term type 2 diabetes is more severe than that in patients with shorter disease duration.
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spelling pubmed-60795252018-08-16 Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus He, Fanglin Zhao, Zhanlin Liu, Yan Lu, Linna Fu, Yao J Ophthalmol Research Article PURPOSE: To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. METHODS: One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore). RESULTS: The noninvasive breakup time first (NIKBUT-1st) and noninvasive breakup time average (NIKBUT-avg) were significantly shorter in the over 10 years diabetic group compared with the control group (P=0.0056  and  P=0.010, resp.). Tear meniscus height (TMH) was significantly lower in the over 10 years diabetic group compared with the control group (P=0.0016) and the 5 years group (P=0.0061). We also found that more patients in the over 10 years diabetic group showed bulbar and limbal hyperemia compared with the control group (bulbar hyperemia: P=0.049; limbal hyperemia: P=0.026). The meiboscore in the over 10 years diabetic group was significantly higher compared with the other three groups (P < 0.05). Bulbar hyperemia showed a significant negative correlation with NIKBUT-1st in the over 10 years diabetic group (r=−0.35  and  P < 0.05). CONCLUSION: Ocular surface damage in long-term type 2 diabetes is more severe than that in patients with shorter disease duration. Hindawi 2018-07-15 /pmc/articles/PMC6079525/ /pubmed/30116624 http://dx.doi.org/10.1155/2018/1206808 Text en Copyright © 2018 Fanglin He et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
He, Fanglin
Zhao, Zhanlin
Liu, Yan
Lu, Linna
Fu, Yao
Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus
title Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus
title_full Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus
title_fullStr Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus
title_full_unstemmed Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus
title_short Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus
title_sort assessment of ocular surface damage during the course of type 2 diabetes mellitus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079525/
https://www.ncbi.nlm.nih.gov/pubmed/30116624
http://dx.doi.org/10.1155/2018/1206808
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