Cargando…
Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus
PURPOSE: To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. METHODS: One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, an...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079525/ https://www.ncbi.nlm.nih.gov/pubmed/30116624 http://dx.doi.org/10.1155/2018/1206808 |
_version_ | 1783345294484701184 |
---|---|
author | He, Fanglin Zhao, Zhanlin Liu, Yan Lu, Linna Fu, Yao |
author_facet | He, Fanglin Zhao, Zhanlin Liu, Yan Lu, Linna Fu, Yao |
author_sort | He, Fanglin |
collection | PubMed |
description | PURPOSE: To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. METHODS: One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore). RESULTS: The noninvasive breakup time first (NIKBUT-1st) and noninvasive breakup time average (NIKBUT-avg) were significantly shorter in the over 10 years diabetic group compared with the control group (P=0.0056 and P=0.010, resp.). Tear meniscus height (TMH) was significantly lower in the over 10 years diabetic group compared with the control group (P=0.0016) and the 5 years group (P=0.0061). We also found that more patients in the over 10 years diabetic group showed bulbar and limbal hyperemia compared with the control group (bulbar hyperemia: P=0.049; limbal hyperemia: P=0.026). The meiboscore in the over 10 years diabetic group was significantly higher compared with the other three groups (P < 0.05). Bulbar hyperemia showed a significant negative correlation with NIKBUT-1st in the over 10 years diabetic group (r=−0.35 and P < 0.05). CONCLUSION: Ocular surface damage in long-term type 2 diabetes is more severe than that in patients with shorter disease duration. |
format | Online Article Text |
id | pubmed-6079525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60795252018-08-16 Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus He, Fanglin Zhao, Zhanlin Liu, Yan Lu, Linna Fu, Yao J Ophthalmol Research Article PURPOSE: To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. METHODS: One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore). RESULTS: The noninvasive breakup time first (NIKBUT-1st) and noninvasive breakup time average (NIKBUT-avg) were significantly shorter in the over 10 years diabetic group compared with the control group (P=0.0056 and P=0.010, resp.). Tear meniscus height (TMH) was significantly lower in the over 10 years diabetic group compared with the control group (P=0.0016) and the 5 years group (P=0.0061). We also found that more patients in the over 10 years diabetic group showed bulbar and limbal hyperemia compared with the control group (bulbar hyperemia: P=0.049; limbal hyperemia: P=0.026). The meiboscore in the over 10 years diabetic group was significantly higher compared with the other three groups (P < 0.05). Bulbar hyperemia showed a significant negative correlation with NIKBUT-1st in the over 10 years diabetic group (r=−0.35 and P < 0.05). CONCLUSION: Ocular surface damage in long-term type 2 diabetes is more severe than that in patients with shorter disease duration. Hindawi 2018-07-15 /pmc/articles/PMC6079525/ /pubmed/30116624 http://dx.doi.org/10.1155/2018/1206808 Text en Copyright © 2018 Fanglin He et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article He, Fanglin Zhao, Zhanlin Liu, Yan Lu, Linna Fu, Yao Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
title | Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
title_full | Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
title_fullStr | Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
title_full_unstemmed | Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
title_short | Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
title_sort | assessment of ocular surface damage during the course of type 2 diabetes mellitus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079525/ https://www.ncbi.nlm.nih.gov/pubmed/30116624 http://dx.doi.org/10.1155/2018/1206808 |
work_keys_str_mv | AT hefanglin assessmentofocularsurfacedamageduringthecourseoftype2diabetesmellitus AT zhaozhanlin assessmentofocularsurfacedamageduringthecourseoftype2diabetesmellitus AT liuyan assessmentofocularsurfacedamageduringthecourseoftype2diabetesmellitus AT lulinna assessmentofocularsurfacedamageduringthecourseoftype2diabetesmellitus AT fuyao assessmentofocularsurfacedamageduringthecourseoftype2diabetesmellitus |