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Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?

Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the...

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Detalles Bibliográficos
Autores principales: Van Wyngene, Lise, Vandewalle, Jolien, Libert, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079534/
https://www.ncbi.nlm.nih.gov/pubmed/29976786
http://dx.doi.org/10.15252/emmm.201708712
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author Van Wyngene, Lise
Vandewalle, Jolien
Libert, Claude
author_facet Van Wyngene, Lise
Vandewalle, Jolien
Libert, Claude
author_sort Van Wyngene, Lise
collection PubMed
description Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the highly catabolic status during sepsis and its similarity with starvation responses appear to be essential in the poor prognosis in sepsis. It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems.
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spelling pubmed-60795342018-08-09 Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? Van Wyngene, Lise Vandewalle, Jolien Libert, Claude EMBO Mol Med Review Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the highly catabolic status during sepsis and its similarity with starvation responses appear to be essential in the poor prognosis in sepsis. It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems. John Wiley and Sons Inc. 2018-07-05 2018-08 /pmc/articles/PMC6079534/ /pubmed/29976786 http://dx.doi.org/10.15252/emmm.201708712 Text en © 2018 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Van Wyngene, Lise
Vandewalle, Jolien
Libert, Claude
Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
title Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
title_full Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
title_fullStr Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
title_full_unstemmed Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
title_short Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
title_sort reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079534/
https://www.ncbi.nlm.nih.gov/pubmed/29976786
http://dx.doi.org/10.15252/emmm.201708712
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