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Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079534/ https://www.ncbi.nlm.nih.gov/pubmed/29976786 http://dx.doi.org/10.15252/emmm.201708712 |
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author | Van Wyngene, Lise Vandewalle, Jolien Libert, Claude |
author_facet | Van Wyngene, Lise Vandewalle, Jolien Libert, Claude |
author_sort | Van Wyngene, Lise |
collection | PubMed |
description | Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the highly catabolic status during sepsis and its similarity with starvation responses appear to be essential in the poor prognosis in sepsis. It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems. |
format | Online Article Text |
id | pubmed-6079534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60795342018-08-09 Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? Van Wyngene, Lise Vandewalle, Jolien Libert, Claude EMBO Mol Med Review Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the highly catabolic status during sepsis and its similarity with starvation responses appear to be essential in the poor prognosis in sepsis. It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems. John Wiley and Sons Inc. 2018-07-05 2018-08 /pmc/articles/PMC6079534/ /pubmed/29976786 http://dx.doi.org/10.15252/emmm.201708712 Text en © 2018 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Van Wyngene, Lise Vandewalle, Jolien Libert, Claude Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
title | Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
title_full | Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
title_fullStr | Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
title_full_unstemmed | Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
title_short | Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
title_sort | reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079534/ https://www.ncbi.nlm.nih.gov/pubmed/29976786 http://dx.doi.org/10.15252/emmm.201708712 |
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