Successful Treatment of Methampyrone-Induced Toxic Epidermal Necrolysis with Therapeutic Plasma Exchange

The toxic epidermal necrolysis (TEN) is a severe cutaneous adverse reaction frequently caused by drug exposure. A 58-year-old male was admitted to the hospital after administration of methampyrone. He developed sloughing of the total epidermis which rapidly extended over the trunk and limbs. The pre...

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Detalles Bibliográficos
Autores principales: Santosa, Rumbiana, A., Wahab, Z., Kurniawan, S. P., Naibaho, R. M., Yogyartono, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079558/
https://www.ncbi.nlm.nih.gov/pubmed/30123277
http://dx.doi.org/10.1155/2018/2182604
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author Santosa,
Rumbiana, A.
Wahab, Z.
Kurniawan, S. P.
Naibaho, R. M.
Yogyartono, P.
author_facet Santosa,
Rumbiana, A.
Wahab, Z.
Kurniawan, S. P.
Naibaho, R. M.
Yogyartono, P.
author_sort Santosa,
collection PubMed
description The toxic epidermal necrolysis (TEN) is a severe cutaneous adverse reaction frequently caused by drug exposure. A 58-year-old male was admitted to the hospital after administration of methampyrone. He developed sloughing of the total epidermis which rapidly extended over the trunk and limbs. The presumptive diagnosis was drug-induced TEN. Despite the treatment with pulsed glucocorticoid and cyclosporine, the skin lesions extended over the entire body. Strikingly, the progression of blistering was stopped by therapeutic plasma exchange (TPE). TPE was discontinued after the signs of skin inflammation had been overcome. He recovered in 8 days of hospitalization. We present here a case of a methampyrone-induced TEN which was successfully treated with TPE.
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spelling pubmed-60795582018-08-19 Successful Treatment of Methampyrone-Induced Toxic Epidermal Necrolysis with Therapeutic Plasma Exchange Santosa, Rumbiana, A. Wahab, Z. Kurniawan, S. P. Naibaho, R. M. Yogyartono, P. Case Rep Med Case Report The toxic epidermal necrolysis (TEN) is a severe cutaneous adverse reaction frequently caused by drug exposure. A 58-year-old male was admitted to the hospital after administration of methampyrone. He developed sloughing of the total epidermis which rapidly extended over the trunk and limbs. The presumptive diagnosis was drug-induced TEN. Despite the treatment with pulsed glucocorticoid and cyclosporine, the skin lesions extended over the entire body. Strikingly, the progression of blistering was stopped by therapeutic plasma exchange (TPE). TPE was discontinued after the signs of skin inflammation had been overcome. He recovered in 8 days of hospitalization. We present here a case of a methampyrone-induced TEN which was successfully treated with TPE. Hindawi 2018-07-18 /pmc/articles/PMC6079558/ /pubmed/30123277 http://dx.doi.org/10.1155/2018/2182604 Text en Copyright © 2018 Santosa et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Santosa,
Rumbiana, A.
Wahab, Z.
Kurniawan, S. P.
Naibaho, R. M.
Yogyartono, P.
Successful Treatment of Methampyrone-Induced Toxic Epidermal Necrolysis with Therapeutic Plasma Exchange
title Successful Treatment of Methampyrone-Induced Toxic Epidermal Necrolysis with Therapeutic Plasma Exchange
title_full Successful Treatment of Methampyrone-Induced Toxic Epidermal Necrolysis with Therapeutic Plasma Exchange
title_fullStr Successful Treatment of Methampyrone-Induced Toxic Epidermal Necrolysis with Therapeutic Plasma Exchange
title_full_unstemmed Successful Treatment of Methampyrone-Induced Toxic Epidermal Necrolysis with Therapeutic Plasma Exchange
title_short Successful Treatment of Methampyrone-Induced Toxic Epidermal Necrolysis with Therapeutic Plasma Exchange
title_sort successful treatment of methampyrone-induced toxic epidermal necrolysis with therapeutic plasma exchange
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079558/
https://www.ncbi.nlm.nih.gov/pubmed/30123277
http://dx.doi.org/10.1155/2018/2182604
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