Cargando…
An Unusual Case of CMV/EBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient
Epstein–Barr virus (EBV) is a well-known cause of different types of malignancies particularly Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's lymphomas, and non-Hodgkin's lymphomas including primary central nervous system lymphoma (PCNSL). A higher tendency of malignant trans...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079612/ https://www.ncbi.nlm.nih.gov/pubmed/30123590 http://dx.doi.org/10.1155/2018/7683797 |
_version_ | 1783345313845608448 |
---|---|
author | Borges, Gisela Neves, Diana Maury, Inês Pintado Pereira, Aida Silva, Maria de Jesus |
author_facet | Borges, Gisela Neves, Diana Maury, Inês Pintado Pereira, Aida Silva, Maria de Jesus |
author_sort | Borges, Gisela |
collection | PubMed |
description | Epstein–Barr virus (EBV) is a well-known cause of different types of malignancies particularly Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's lymphomas, and non-Hodgkin's lymphomas including primary central nervous system lymphoma (PCNSL). A higher tendency of malignant transformation associated with EBV has been noticed in immunocompromised patients, such as human immunodeficiency virus (HIV) infected patients. The rapid and effective immune reconstitution is crucial to prevent PCNSL in HIV-positive patients. We present a clinical case of a young patient diagnosed with HIV infection and medicated with antiretroviral therapy (ART) with poor immunological recovery. After two weeks, he developed ventriculoencephalitis, observed in the cranial magnetic resonance imaging (MRI), caused by cytomegalovirus (CMV) and EBV, both with high serum viral load, rapidly evolving to PCNSL. With this unusual clinical case, the authors want to draw attention to the importance of rapid immunological reconstitution in preventing the progression of EBV infection to PCNSL, as well as encouraging the confirmation of the usefulness of early combination of chemotherapy and antiviral therapy, in order to reach a more effective treatment of this herpesvirus infection and associated malignancies. |
format | Online Article Text |
id | pubmed-6079612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60796122018-08-19 An Unusual Case of CMV/EBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient Borges, Gisela Neves, Diana Maury, Inês Pintado Pereira, Aida Silva, Maria de Jesus Case Rep Infect Dis Case Report Epstein–Barr virus (EBV) is a well-known cause of different types of malignancies particularly Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's lymphomas, and non-Hodgkin's lymphomas including primary central nervous system lymphoma (PCNSL). A higher tendency of malignant transformation associated with EBV has been noticed in immunocompromised patients, such as human immunodeficiency virus (HIV) infected patients. The rapid and effective immune reconstitution is crucial to prevent PCNSL in HIV-positive patients. We present a clinical case of a young patient diagnosed with HIV infection and medicated with antiretroviral therapy (ART) with poor immunological recovery. After two weeks, he developed ventriculoencephalitis, observed in the cranial magnetic resonance imaging (MRI), caused by cytomegalovirus (CMV) and EBV, both with high serum viral load, rapidly evolving to PCNSL. With this unusual clinical case, the authors want to draw attention to the importance of rapid immunological reconstitution in preventing the progression of EBV infection to PCNSL, as well as encouraging the confirmation of the usefulness of early combination of chemotherapy and antiviral therapy, in order to reach a more effective treatment of this herpesvirus infection and associated malignancies. Hindawi 2018-07-17 /pmc/articles/PMC6079612/ /pubmed/30123590 http://dx.doi.org/10.1155/2018/7683797 Text en Copyright © 2018 Gisela Borges et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Borges, Gisela Neves, Diana Maury, Inês Pintado Pereira, Aida Silva, Maria de Jesus An Unusual Case of CMV/EBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient |
title | An Unusual Case of CMV/EBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient |
title_full | An Unusual Case of CMV/EBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient |
title_fullStr | An Unusual Case of CMV/EBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient |
title_full_unstemmed | An Unusual Case of CMV/EBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient |
title_short | An Unusual Case of CMV/EBV Ventriculoencephalitis with Evolution to Primary Central Nervous System Lymphoma in HIV-Positive Patient |
title_sort | unusual case of cmv/ebv ventriculoencephalitis with evolution to primary central nervous system lymphoma in hiv-positive patient |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079612/ https://www.ncbi.nlm.nih.gov/pubmed/30123590 http://dx.doi.org/10.1155/2018/7683797 |
work_keys_str_mv | AT borgesgisela anunusualcaseofcmvebvventriculoencephalitiswithevolutiontoprimarycentralnervoussystemlymphomainhivpositivepatient AT nevesdiana anunusualcaseofcmvebvventriculoencephalitiswithevolutiontoprimarycentralnervoussystemlymphomainhivpositivepatient AT mauryinespintado anunusualcaseofcmvebvventriculoencephalitiswithevolutiontoprimarycentralnervoussystemlymphomainhivpositivepatient AT pereiraaida anunusualcaseofcmvebvventriculoencephalitiswithevolutiontoprimarycentralnervoussystemlymphomainhivpositivepatient AT silvamariadejesus anunusualcaseofcmvebvventriculoencephalitiswithevolutiontoprimarycentralnervoussystemlymphomainhivpositivepatient AT borgesgisela unusualcaseofcmvebvventriculoencephalitiswithevolutiontoprimarycentralnervoussystemlymphomainhivpositivepatient AT nevesdiana unusualcaseofcmvebvventriculoencephalitiswithevolutiontoprimarycentralnervoussystemlymphomainhivpositivepatient AT mauryinespintado unusualcaseofcmvebvventriculoencephalitiswithevolutiontoprimarycentralnervoussystemlymphomainhivpositivepatient AT pereiraaida unusualcaseofcmvebvventriculoencephalitiswithevolutiontoprimarycentralnervoussystemlymphomainhivpositivepatient AT silvamariadejesus unusualcaseofcmvebvventriculoencephalitiswithevolutiontoprimarycentralnervoussystemlymphomainhivpositivepatient |