A Nexus model of cellular transition in cancer

The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the cause. The model of cancer proposed herein, provides a link between the cellular biochemist...

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Autores principales: Yadav, Mukesh, Chatterjee, Payal, Tolani, Simran, Kulkarni, Jaya, Mulye, Meenakshi, Chauhan, Namrata, Sakhi, Aditi, Gorey, Sakshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080350/
https://www.ncbi.nlm.nih.gov/pubmed/30086794
http://dx.doi.org/10.1186/s40659-018-0173-8
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author Yadav, Mukesh
Chatterjee, Payal
Tolani, Simran
Kulkarni, Jaya
Mulye, Meenakshi
Chauhan, Namrata
Sakhi, Aditi
Gorey, Sakshi
author_facet Yadav, Mukesh
Chatterjee, Payal
Tolani, Simran
Kulkarni, Jaya
Mulye, Meenakshi
Chauhan, Namrata
Sakhi, Aditi
Gorey, Sakshi
author_sort Yadav, Mukesh
collection PubMed
description The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the cause. The model of cancer proposed herein, provides a link between the cellular biochemistry and cellular genetics of cancer evolution. We thus call this model as the “Nexus model” of cancer. The Nexus model is an effort to identify the most apparent route to the disease. We have tried to utilize existing cancer literature to identify the most plausible causes of cellular transition in cancer, where the primary cancer-causing agents (physical, chemical or biological) act as inducing factors to produce cellular impeders. These cellular impeders are further linked to the Nexus. The Nexus then generates codes for epigenetics and genetics in cancer development.
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spelling pubmed-60803502018-08-09 A Nexus model of cellular transition in cancer Yadav, Mukesh Chatterjee, Payal Tolani, Simran Kulkarni, Jaya Mulye, Meenakshi Chauhan, Namrata Sakhi, Aditi Gorey, Sakshi Biol Res Review The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the cause. The model of cancer proposed herein, provides a link between the cellular biochemistry and cellular genetics of cancer evolution. We thus call this model as the “Nexus model” of cancer. The Nexus model is an effort to identify the most apparent route to the disease. We have tried to utilize existing cancer literature to identify the most plausible causes of cellular transition in cancer, where the primary cancer-causing agents (physical, chemical or biological) act as inducing factors to produce cellular impeders. These cellular impeders are further linked to the Nexus. The Nexus then generates codes for epigenetics and genetics in cancer development. BioMed Central 2018-08-07 /pmc/articles/PMC6080350/ /pubmed/30086794 http://dx.doi.org/10.1186/s40659-018-0173-8 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Yadav, Mukesh
Chatterjee, Payal
Tolani, Simran
Kulkarni, Jaya
Mulye, Meenakshi
Chauhan, Namrata
Sakhi, Aditi
Gorey, Sakshi
A Nexus model of cellular transition in cancer
title A Nexus model of cellular transition in cancer
title_full A Nexus model of cellular transition in cancer
title_fullStr A Nexus model of cellular transition in cancer
title_full_unstemmed A Nexus model of cellular transition in cancer
title_short A Nexus model of cellular transition in cancer
title_sort nexus model of cellular transition in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080350/
https://www.ncbi.nlm.nih.gov/pubmed/30086794
http://dx.doi.org/10.1186/s40659-018-0173-8
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