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The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses

The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of sufficient quality and breadth for protection. In this r...

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Detalles Bibliográficos
Autores principales: Moysi, Eirini, Petrovas, Constantinos, Koup, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080353/
https://www.ncbi.nlm.nih.gov/pubmed/30081906
http://dx.doi.org/10.1186/s12977-018-0437-y
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author Moysi, Eirini
Petrovas, Constantinos
Koup, Richard A.
author_facet Moysi, Eirini
Petrovas, Constantinos
Koup, Richard A.
author_sort Moysi, Eirini
collection PubMed
description The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of sufficient quality and breadth for protection. In this review, we focus on the role of follicular helper CD4 T-cells (Tfh) in the development of such cross-reactive protective antibodies. We discuss germinal center (GC) formation and the dynamics of Tfh and GC B cells during HIV-1/SIV infection and vaccination. Finally, we consider future directions for the study of Tfh and offer perspective on factors that could be modulated to enhance Tfh function in the context of prophylactic vaccination.
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spelling pubmed-60803532018-08-09 The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses Moysi, Eirini Petrovas, Constantinos Koup, Richard A. Retrovirology Review The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of sufficient quality and breadth for protection. In this review, we focus on the role of follicular helper CD4 T-cells (Tfh) in the development of such cross-reactive protective antibodies. We discuss germinal center (GC) formation and the dynamics of Tfh and GC B cells during HIV-1/SIV infection and vaccination. Finally, we consider future directions for the study of Tfh and offer perspective on factors that could be modulated to enhance Tfh function in the context of prophylactic vaccination. BioMed Central 2018-08-06 /pmc/articles/PMC6080353/ /pubmed/30081906 http://dx.doi.org/10.1186/s12977-018-0437-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Moysi, Eirini
Petrovas, Constantinos
Koup, Richard A.
The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses
title The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses
title_full The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses
title_fullStr The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses
title_full_unstemmed The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses
title_short The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses
title_sort role of follicular helper cd4 t cells in the development of hiv-1 specific broadly neutralizing antibody responses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080353/
https://www.ncbi.nlm.nih.gov/pubmed/30081906
http://dx.doi.org/10.1186/s12977-018-0437-y
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