Cargando…
The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses
The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of sufficient quality and breadth for protection. In this r...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080353/ https://www.ncbi.nlm.nih.gov/pubmed/30081906 http://dx.doi.org/10.1186/s12977-018-0437-y |
_version_ | 1783345458207260672 |
---|---|
author | Moysi, Eirini Petrovas, Constantinos Koup, Richard A. |
author_facet | Moysi, Eirini Petrovas, Constantinos Koup, Richard A. |
author_sort | Moysi, Eirini |
collection | PubMed |
description | The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of sufficient quality and breadth for protection. In this review, we focus on the role of follicular helper CD4 T-cells (Tfh) in the development of such cross-reactive protective antibodies. We discuss germinal center (GC) formation and the dynamics of Tfh and GC B cells during HIV-1/SIV infection and vaccination. Finally, we consider future directions for the study of Tfh and offer perspective on factors that could be modulated to enhance Tfh function in the context of prophylactic vaccination. |
format | Online Article Text |
id | pubmed-6080353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60803532018-08-09 The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses Moysi, Eirini Petrovas, Constantinos Koup, Richard A. Retrovirology Review The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited broadly neutralizing antibodies of sufficient quality and breadth for protection. In this review, we focus on the role of follicular helper CD4 T-cells (Tfh) in the development of such cross-reactive protective antibodies. We discuss germinal center (GC) formation and the dynamics of Tfh and GC B cells during HIV-1/SIV infection and vaccination. Finally, we consider future directions for the study of Tfh and offer perspective on factors that could be modulated to enhance Tfh function in the context of prophylactic vaccination. BioMed Central 2018-08-06 /pmc/articles/PMC6080353/ /pubmed/30081906 http://dx.doi.org/10.1186/s12977-018-0437-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Moysi, Eirini Petrovas, Constantinos Koup, Richard A. The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
title | The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
title_full | The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
title_fullStr | The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
title_full_unstemmed | The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
title_short | The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses |
title_sort | role of follicular helper cd4 t cells in the development of hiv-1 specific broadly neutralizing antibody responses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080353/ https://www.ncbi.nlm.nih.gov/pubmed/30081906 http://dx.doi.org/10.1186/s12977-018-0437-y |
work_keys_str_mv | AT moysieirini theroleoffollicularhelpercd4tcellsinthedevelopmentofhiv1specificbroadlyneutralizingantibodyresponses AT petrovasconstantinos theroleoffollicularhelpercd4tcellsinthedevelopmentofhiv1specificbroadlyneutralizingantibodyresponses AT koupricharda theroleoffollicularhelpercd4tcellsinthedevelopmentofhiv1specificbroadlyneutralizingantibodyresponses AT moysieirini roleoffollicularhelpercd4tcellsinthedevelopmentofhiv1specificbroadlyneutralizingantibodyresponses AT petrovasconstantinos roleoffollicularhelpercd4tcellsinthedevelopmentofhiv1specificbroadlyneutralizingantibodyresponses AT koupricharda roleoffollicularhelpercd4tcellsinthedevelopmentofhiv1specificbroadlyneutralizingantibodyresponses |