Functional implications of Rab27 GTPases in Cancer

BACKGROUND: The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment. MAIN BODY: Elevated expression o...

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Detalles Bibliográficos
Autores principales: Li, Zhihong, Fang, Rui, Fang, Jia, He, Shasha, Liu, Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080553/
https://www.ncbi.nlm.nih.gov/pubmed/30081925
http://dx.doi.org/10.1186/s12964-018-0255-9
Descripción
Sumario:BACKGROUND: The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment. MAIN BODY: Elevated expression of Rab27 GTPases is associated with poor prognosis and cancer metastasis. Moreover, these GTPases govern a variety of oncogenic functions, including cell proliferation, cell motility, and chemosensitivity. In addition, small GTPases promote tumor growth and metastasis by enhancing exosome secretion, which alters intracellular microRNA levels, signaling molecule expression, and the tumor microenvironment. CONCLUSION: Rab27 GTPases may have applications as prognostic markers and therapeutic targets in cancer treatment.

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