Functional implications of Rab27 GTPases in Cancer

BACKGROUND: The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment. MAIN BODY: Elevated expression o...

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Detalles Bibliográficos
Autores principales: Li, Zhihong, Fang, Rui, Fang, Jia, He, Shasha, Liu, Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080553/
https://www.ncbi.nlm.nih.gov/pubmed/30081925
http://dx.doi.org/10.1186/s12964-018-0255-9
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author Li, Zhihong
Fang, Rui
Fang, Jia
He, Shasha
Liu, Tang
author_facet Li, Zhihong
Fang, Rui
Fang, Jia
He, Shasha
Liu, Tang
author_sort Li, Zhihong
collection PubMed
description BACKGROUND: The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment. MAIN BODY: Elevated expression of Rab27 GTPases is associated with poor prognosis and cancer metastasis. Moreover, these GTPases govern a variety of oncogenic functions, including cell proliferation, cell motility, and chemosensitivity. In addition, small GTPases promote tumor growth and metastasis by enhancing exosome secretion, which alters intracellular microRNA levels, signaling molecule expression, and the tumor microenvironment. CONCLUSION: Rab27 GTPases may have applications as prognostic markers and therapeutic targets in cancer treatment.
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spelling pubmed-60805532018-08-09 Functional implications of Rab27 GTPases in Cancer Li, Zhihong Fang, Rui Fang, Jia He, Shasha Liu, Tang Cell Commun Signal Review BACKGROUND: The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment. MAIN BODY: Elevated expression of Rab27 GTPases is associated with poor prognosis and cancer metastasis. Moreover, these GTPases govern a variety of oncogenic functions, including cell proliferation, cell motility, and chemosensitivity. In addition, small GTPases promote tumor growth and metastasis by enhancing exosome secretion, which alters intracellular microRNA levels, signaling molecule expression, and the tumor microenvironment. CONCLUSION: Rab27 GTPases may have applications as prognostic markers and therapeutic targets in cancer treatment. BioMed Central 2018-08-06 /pmc/articles/PMC6080553/ /pubmed/30081925 http://dx.doi.org/10.1186/s12964-018-0255-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Li, Zhihong
Fang, Rui
Fang, Jia
He, Shasha
Liu, Tang
Functional implications of Rab27 GTPases in Cancer
title Functional implications of Rab27 GTPases in Cancer
title_full Functional implications of Rab27 GTPases in Cancer
title_fullStr Functional implications of Rab27 GTPases in Cancer
title_full_unstemmed Functional implications of Rab27 GTPases in Cancer
title_short Functional implications of Rab27 GTPases in Cancer
title_sort functional implications of rab27 gtpases in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080553/
https://www.ncbi.nlm.nih.gov/pubmed/30081925
http://dx.doi.org/10.1186/s12964-018-0255-9
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AT liutang functionalimplicationsofrab27gtpasesincancer

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