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Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1–Tea4–Pom1 axis

The conserved Rho-family GTPase Cdc42 plays a central role in eukaryotic cell polarity. The rod-shaped fission yeast Schizosaccharomyces pombe has two Cdc42 guanine nucleotide exchange factors (GEFs), Scd1 and Gef1, but little is known about how they are coordinated in polarized growth. Although the...

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Detalles Bibliográficos
Autores principales: Tay, Ye Dee, Leda, Marcin, Goryachev, Andrew B., Sawin, Kenneth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080602/
https://www.ncbi.nlm.nih.gov/pubmed/29930085
http://dx.doi.org/10.1242/jcs.216580