Mouse models of sporadic thyroid cancer derived from BRAF(V600E) alone or in combination with PTEN haploinsufficiency under physiologic TSH levels

The BRAF(V600E) mutation is the most prevalent driver mutation of sporadic papillary thyroid cancers (PTC). It was previously shown that prenatal or postnatal expression of BRAF(V600E) under elevated TSH levels induced thyroid cancers in several genetically engineered mouse models. In contrast, we f...

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Detalles Bibliográficos
Autores principales: Shimamura, Mika, Shibusawa, Nobuyuki, Kurashige, Tomomi, Mussazhanova, Zhanna, Matsuzaki, Hiroki, Nakashima, Masahiro, Yamada, Masanobu, Nagayama, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080762/
https://www.ncbi.nlm.nih.gov/pubmed/30086162
http://dx.doi.org/10.1371/journal.pone.0201365

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