Chronic schistosomiasis suppresses HIV-specific responses to DNA-MVA and MVA-gp140 Env vaccine regimens despite antihelminthic treatment and increases helminth-associated pathology in a mouse model

Future HIV vaccines are expected to induce effective Th1 cell-mediated and Env-specific antibody responses that are necessary to offer protective immunity to HIV infection. However, HIV infections are highly prevalent in helminth endemic areas. Helminth infections induce polarised Th2 responses that...

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Detalles Bibliográficos
Autores principales: Dzhivhuho, Godfrey A., Rehrl, Samantha A., Ndlovu, Hlumani, Horsnell, William G. C., Brombacher, Frank, Williamson, Anna-Lise, Chege, Gerald K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080792/
https://www.ncbi.nlm.nih.gov/pubmed/30048550
http://dx.doi.org/10.1371/journal.ppat.1007182

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