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Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N(2)O for recreational use: a case report
N(2)O, or laughing gas, is generally used for anesthesia, especially in stomatology and pediatrics but is also commonly used recreationally. Cognitive dysfunction induced by the recreational use of N(2)O is rare. Here, we present the case of an 18-year-old female with a history of having used N(2)O...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080867/ https://www.ncbi.nlm.nih.gov/pubmed/30122928 http://dx.doi.org/10.2147/NDT.S170037 |
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author | Luo, Dan Xu, Jiajun Hu, Li Yu, Liangming Xie, Leling Li, Jing |
author_facet | Luo, Dan Xu, Jiajun Hu, Li Yu, Liangming Xie, Leling Li, Jing |
author_sort | Luo, Dan |
collection | PubMed |
description | N(2)O, or laughing gas, is generally used for anesthesia, especially in stomatology and pediatrics but is also commonly used recreationally. Cognitive dysfunction induced by the recreational use of N(2)O is rare. Here, we present the case of an 18-year-old female with a history of having used N(2)O recreationally for 5 months who suffered from encephalatrophy and severe cognitive dysfunction. All of the symptoms gradually subsided with ~20 days of treatment by hyperbaric oxygenation. We hypothesize that the long-term use of N(2)O may have induced a chronic state of systemic hypoxia that further induced cerebral atrophy with impaired cognitive function. Hyperbaric oxygen therapy (HBOT) is reported here for the first time as an important therapeutic element for treating N(2)O toxicity due to recreational use. |
format | Online Article Text |
id | pubmed-6080867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60808672018-08-17 Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N(2)O for recreational use: a case report Luo, Dan Xu, Jiajun Hu, Li Yu, Liangming Xie, Leling Li, Jing Neuropsychiatr Dis Treat Case Report N(2)O, or laughing gas, is generally used for anesthesia, especially in stomatology and pediatrics but is also commonly used recreationally. Cognitive dysfunction induced by the recreational use of N(2)O is rare. Here, we present the case of an 18-year-old female with a history of having used N(2)O recreationally for 5 months who suffered from encephalatrophy and severe cognitive dysfunction. All of the symptoms gradually subsided with ~20 days of treatment by hyperbaric oxygenation. We hypothesize that the long-term use of N(2)O may have induced a chronic state of systemic hypoxia that further induced cerebral atrophy with impaired cognitive function. Hyperbaric oxygen therapy (HBOT) is reported here for the first time as an important therapeutic element for treating N(2)O toxicity due to recreational use. Dove Medical Press 2018-08-03 /pmc/articles/PMC6080867/ /pubmed/30122928 http://dx.doi.org/10.2147/NDT.S170037 Text en © 2018 Luo et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Report Luo, Dan Xu, Jiajun Hu, Li Yu, Liangming Xie, Leling Li, Jing Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N(2)O for recreational use: a case report |
title | Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N(2)O for recreational use: a case report |
title_full | Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N(2)O for recreational use: a case report |
title_fullStr | Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N(2)O for recreational use: a case report |
title_full_unstemmed | Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N(2)O for recreational use: a case report |
title_short | Hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by N(2)O for recreational use: a case report |
title_sort | hyperbaric oxygen therapy to improve cognitive dysfunction and encephalatrophy induced by n(2)o for recreational use: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080867/ https://www.ncbi.nlm.nih.gov/pubmed/30122928 http://dx.doi.org/10.2147/NDT.S170037 |
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