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Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study

PURPOSE: We aimed to evaluate the association of serum uric acid on admission with long-term outcome of critically ill patients. MATERIALS AND METHODS: We conducted a retrospective cohort study using data extracted from the Medical Information Mart for Intensive Care III database. The primary endpoi...

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Autores principales: Chen, Qinchang, Huang, Kai, Li, Lingling, Lin, Xixia, Ding, Cong, Zhang, Junrui, Chen, Qingui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080869/
https://www.ncbi.nlm.nih.gov/pubmed/30122934
http://dx.doi.org/10.2147/TCRM.S170647
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author Chen, Qinchang
Huang, Kai
Li, Lingling
Lin, Xixia
Ding, Cong
Zhang, Junrui
Chen, Qingui
author_facet Chen, Qinchang
Huang, Kai
Li, Lingling
Lin, Xixia
Ding, Cong
Zhang, Junrui
Chen, Qingui
author_sort Chen, Qinchang
collection PubMed
description PURPOSE: We aimed to evaluate the association of serum uric acid on admission with long-term outcome of critically ill patients. MATERIALS AND METHODS: We conducted a retrospective cohort study using data extracted from the Medical Information Mart for Intensive Care III database. The primary endpoint was 90-day mortality. Propensity score matching (PSM) was performed, and multivariate Cox regression analysis was used to adjust for potential confounders. Receiver operating characteristic (ROC) curves were also used to assess the mortality predictions. RESULTS: A total of 2,123 patients were included finally with a PSM cohort consisting of 556 90-day non-survivors matched 1:1 with 556 90-day survivors. No statistically significant difference of median admission uric acid was observed between the two groups (survivors 5.50 mg/dL vs non-survivors 5.60 mg/dL, p=0.536). ROC area under the curve was 0.511 (95% confidence interval [CI] 0.477–0.545), suggesting that uric acid had poor discriminative powers for predicting 90-day mortality. No significant association between uric acid and 90-day mortality was found (hazard ratio 1.00, 95% CI 0.98–1.03, p=0.6835). CONCLUSION: Serum uric acid on intensive care unit admission failed to predict 90-day mortality of critically ill patients.
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spelling pubmed-60808692018-08-17 Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study Chen, Qinchang Huang, Kai Li, Lingling Lin, Xixia Ding, Cong Zhang, Junrui Chen, Qingui Ther Clin Risk Manag Original Research PURPOSE: We aimed to evaluate the association of serum uric acid on admission with long-term outcome of critically ill patients. MATERIALS AND METHODS: We conducted a retrospective cohort study using data extracted from the Medical Information Mart for Intensive Care III database. The primary endpoint was 90-day mortality. Propensity score matching (PSM) was performed, and multivariate Cox regression analysis was used to adjust for potential confounders. Receiver operating characteristic (ROC) curves were also used to assess the mortality predictions. RESULTS: A total of 2,123 patients were included finally with a PSM cohort consisting of 556 90-day non-survivors matched 1:1 with 556 90-day survivors. No statistically significant difference of median admission uric acid was observed between the two groups (survivors 5.50 mg/dL vs non-survivors 5.60 mg/dL, p=0.536). ROC area under the curve was 0.511 (95% confidence interval [CI] 0.477–0.545), suggesting that uric acid had poor discriminative powers for predicting 90-day mortality. No significant association between uric acid and 90-day mortality was found (hazard ratio 1.00, 95% CI 0.98–1.03, p=0.6835). CONCLUSION: Serum uric acid on intensive care unit admission failed to predict 90-day mortality of critically ill patients. Dove Medical Press 2018-08-02 /pmc/articles/PMC6080869/ /pubmed/30122934 http://dx.doi.org/10.2147/TCRM.S170647 Text en © 2018 Chen et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Chen, Qinchang
Huang, Kai
Li, Lingling
Lin, Xixia
Ding, Cong
Zhang, Junrui
Chen, Qingui
Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study
title Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study
title_full Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study
title_fullStr Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study
title_full_unstemmed Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study
title_short Serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study
title_sort serum uric acid on admission cannot predict long-term outcome of critically ill patients: a retrospective cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080869/
https://www.ncbi.nlm.nih.gov/pubmed/30122934
http://dx.doi.org/10.2147/TCRM.S170647
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