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Overview of advances in vasculogenic mimicry – a potential target for tumor therapy
Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells to generate vascular-like structures without the presence of endothelial cells. VM has been vividly described in various tumors and participates in cancer progression dissemination and metastasis. Diverse mole...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080880/ https://www.ncbi.nlm.nih.gov/pubmed/30122992 http://dx.doi.org/10.2147/CMAR.S164675 |
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author | Ge, Hong Luo, Hui |
author_facet | Ge, Hong Luo, Hui |
author_sort | Ge, Hong |
collection | PubMed |
description | Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells to generate vascular-like structures without the presence of endothelial cells. VM has been vividly described in various tumors and participates in cancer progression dissemination and metastasis. Diverse molecular mechanisms and signaling pathways are involved in VM formation. Furthermore, the patterning characteristics of VM, detected with molecular imaging, are being investigated for use as a tool to aid clinical practice. This review explores the most recent studies investigating the role of VM in tumor induction. Indeed, the recognition of these advances will increasingly affect the development of novel therapeutic target strategies for VM in human cancer. |
format | Online Article Text |
id | pubmed-6080880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60808802018-08-17 Overview of advances in vasculogenic mimicry – a potential target for tumor therapy Ge, Hong Luo, Hui Cancer Manag Res Review Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells to generate vascular-like structures without the presence of endothelial cells. VM has been vividly described in various tumors and participates in cancer progression dissemination and metastasis. Diverse molecular mechanisms and signaling pathways are involved in VM formation. Furthermore, the patterning characteristics of VM, detected with molecular imaging, are being investigated for use as a tool to aid clinical practice. This review explores the most recent studies investigating the role of VM in tumor induction. Indeed, the recognition of these advances will increasingly affect the development of novel therapeutic target strategies for VM in human cancer. Dove Medical Press 2018-08-02 /pmc/articles/PMC6080880/ /pubmed/30122992 http://dx.doi.org/10.2147/CMAR.S164675 Text en © 2018 Ge and Luo. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Ge, Hong Luo, Hui Overview of advances in vasculogenic mimicry – a potential target for tumor therapy |
title | Overview of advances in vasculogenic mimicry – a potential target for tumor therapy |
title_full | Overview of advances in vasculogenic mimicry – a potential target for tumor therapy |
title_fullStr | Overview of advances in vasculogenic mimicry – a potential target for tumor therapy |
title_full_unstemmed | Overview of advances in vasculogenic mimicry – a potential target for tumor therapy |
title_short | Overview of advances in vasculogenic mimicry – a potential target for tumor therapy |
title_sort | overview of advances in vasculogenic mimicry – a potential target for tumor therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080880/ https://www.ncbi.nlm.nih.gov/pubmed/30122992 http://dx.doi.org/10.2147/CMAR.S164675 |
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