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Overview of advances in vasculogenic mimicry – a potential target for tumor therapy

Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells to generate vascular-like structures without the presence of endothelial cells. VM has been vividly described in various tumors and participates in cancer progression dissemination and metastasis. Diverse mole...

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Detalles Bibliográficos
Autores principales: Ge, Hong, Luo, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080880/
https://www.ncbi.nlm.nih.gov/pubmed/30122992
http://dx.doi.org/10.2147/CMAR.S164675
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author Ge, Hong
Luo, Hui
author_facet Ge, Hong
Luo, Hui
author_sort Ge, Hong
collection PubMed
description Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells to generate vascular-like structures without the presence of endothelial cells. VM has been vividly described in various tumors and participates in cancer progression dissemination and metastasis. Diverse molecular mechanisms and signaling pathways are involved in VM formation. Furthermore, the patterning characteristics of VM, detected with molecular imaging, are being investigated for use as a tool to aid clinical practice. This review explores the most recent studies investigating the role of VM in tumor induction. Indeed, the recognition of these advances will increasingly affect the development of novel therapeutic target strategies for VM in human cancer.
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spelling pubmed-60808802018-08-17 Overview of advances in vasculogenic mimicry – a potential target for tumor therapy Ge, Hong Luo, Hui Cancer Manag Res Review Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells to generate vascular-like structures without the presence of endothelial cells. VM has been vividly described in various tumors and participates in cancer progression dissemination and metastasis. Diverse molecular mechanisms and signaling pathways are involved in VM formation. Furthermore, the patterning characteristics of VM, detected with molecular imaging, are being investigated for use as a tool to aid clinical practice. This review explores the most recent studies investigating the role of VM in tumor induction. Indeed, the recognition of these advances will increasingly affect the development of novel therapeutic target strategies for VM in human cancer. Dove Medical Press 2018-08-02 /pmc/articles/PMC6080880/ /pubmed/30122992 http://dx.doi.org/10.2147/CMAR.S164675 Text en © 2018 Ge and Luo. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Ge, Hong
Luo, Hui
Overview of advances in vasculogenic mimicry – a potential target for tumor therapy
title Overview of advances in vasculogenic mimicry – a potential target for tumor therapy
title_full Overview of advances in vasculogenic mimicry – a potential target for tumor therapy
title_fullStr Overview of advances in vasculogenic mimicry – a potential target for tumor therapy
title_full_unstemmed Overview of advances in vasculogenic mimicry – a potential target for tumor therapy
title_short Overview of advances in vasculogenic mimicry – a potential target for tumor therapy
title_sort overview of advances in vasculogenic mimicry – a potential target for tumor therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080880/
https://www.ncbi.nlm.nih.gov/pubmed/30122992
http://dx.doi.org/10.2147/CMAR.S164675
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