Biaryl sulfonamide motifs up- or down-regulate ion channel activity by activating voltage sensors

Voltage-gated ion channels are key molecules for the generation of cellular electrical excitability. Many pharmaceutical drugs target these channels by blocking their ion-conducting pore, but in many cases, channel-opening compounds would be more beneficial. Here, to search for new channel-opening c...

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Detalles Bibliográficos
Autores principales: Liin, Sara I., Lund, Per-Eric, Larsson, Johan E., Brask, Johan, Wallner, Björn, Elinder, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080886/
https://www.ncbi.nlm.nih.gov/pubmed/30002162
http://dx.doi.org/10.1085/jgp.201711942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080886/
https://www.ncbi.nlm.nih.gov/pubmed/30002162
http://dx.doi.org/10.1085/jgp.201711942

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