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Biaryl sulfonamide motifs up- or down-regulate ion channel activity by activating voltage sensors
Voltage-gated ion channels are key molecules for the generation of cellular electrical excitability. Many pharmaceutical drugs target these channels by blocking their ion-conducting pore, but in many cases, channel-opening compounds would be more beneficial. Here, to search for new channel-opening c...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080886/ https://www.ncbi.nlm.nih.gov/pubmed/30002162 http://dx.doi.org/10.1085/jgp.201711942 |