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A forward genetic screen identifies chaperone CNX-1 as a conserved biogenesis regulator of ERG K(+) channels

The human ether-a-go-go–related gene (hERG) encodes a voltage-gated potassium channel that controls repolarization of cardiac action potentials. Accumulating evidence suggests that most disease-related hERG mutations reduce the function of the channel by disrupting protein biogenesis of the channel...

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Detalles Bibliográficos
Autores principales:	Bai, Xue, Li, Kai, Yao, Li, Kang, Xin-Lei, Cai, Shi-Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080891/ https://www.ncbi.nlm.nih.gov/pubmed/29941431 http://dx.doi.org/10.1085/jgp.201812025

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