Ca(2+)tapulting HSCs into action

In this issue of JEM, Umemoto et al. (https://doi.org/10.1084/jem.20180421) demonstrate that calcium influx stimulates mitochondrial metabolism and initiates proliferation in hematopoietic stem cells (HSCs). Extracellular adenosine, sourced from surrounding hematopoietic progenitors, inhibits this c...

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Detalles Bibliográficos
Autores principales: Guitart, Amelie V., Finch, Andrew J., Kranc, Kamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080906/
https://www.ncbi.nlm.nih.gov/pubmed/30002075
http://dx.doi.org/10.1084/jem.20181097
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author Guitart, Amelie V.
Finch, Andrew J.
Kranc, Kamil R.
author_facet Guitart, Amelie V.
Finch, Andrew J.
Kranc, Kamil R.
author_sort Guitart, Amelie V.
collection PubMed
description In this issue of JEM, Umemoto et al. (https://doi.org/10.1084/jem.20180421) demonstrate that calcium influx stimulates mitochondrial metabolism and initiates proliferation in hematopoietic stem cells (HSCs). Extracellular adenosine, sourced from surrounding hematopoietic progenitors, inhibits this calcium influx, thereby suppressing mitochondrial metabolism and promoting HSC quiescence. This is the first demonstration that a calcium–mitochondria pathway regulates HSC division.
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spelling pubmed-60809062019-02-06 Ca(2+)tapulting HSCs into action Guitart, Amelie V. Finch, Andrew J. Kranc, Kamil R. J Exp Med News In this issue of JEM, Umemoto et al. (https://doi.org/10.1084/jem.20180421) demonstrate that calcium influx stimulates mitochondrial metabolism and initiates proliferation in hematopoietic stem cells (HSCs). Extracellular adenosine, sourced from surrounding hematopoietic progenitors, inhibits this calcium influx, thereby suppressing mitochondrial metabolism and promoting HSC quiescence. This is the first demonstration that a calcium–mitochondria pathway regulates HSC division. Rockefeller University Press 2018-08-06 /pmc/articles/PMC6080906/ /pubmed/30002075 http://dx.doi.org/10.1084/jem.20181097 Text en © 2018 Guitart et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Guitart, Amelie V.
Finch, Andrew J.
Kranc, Kamil R.
Ca(2+)tapulting HSCs into action
title Ca(2+)tapulting HSCs into action
title_full Ca(2+)tapulting HSCs into action
title_fullStr Ca(2+)tapulting HSCs into action
title_full_unstemmed Ca(2+)tapulting HSCs into action
title_short Ca(2+)tapulting HSCs into action
title_sort ca(2+)tapulting hscs into action
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080906/
https://www.ncbi.nlm.nih.gov/pubmed/30002075
http://dx.doi.org/10.1084/jem.20181097
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