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Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation
Eosinophils are predominantly known for their contribution to allergy. Here, we have examined the function and regulation of gastrointestinal eosinophils in the steady-state and during infection with Helicobacter pylori or Citrobacter rodentium. We find that eosinophils are recruited to sites of inf...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080907/ https://www.ncbi.nlm.nih.gov/pubmed/29970473 http://dx.doi.org/10.1084/jem.20172049 |
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author | Arnold, Isabelle C. Artola-Borán, Mariela Tallón de Lara, Paulino Kyburz, Andreas Taube, Christian Ottemann, Karen van den Broek, Maries Yousefi, Shida Simon, Hans-Uwe Müller, Anne |
author_facet | Arnold, Isabelle C. Artola-Borán, Mariela Tallón de Lara, Paulino Kyburz, Andreas Taube, Christian Ottemann, Karen van den Broek, Maries Yousefi, Shida Simon, Hans-Uwe Müller, Anne |
author_sort | Arnold, Isabelle C. |
collection | PubMed |
description | Eosinophils are predominantly known for their contribution to allergy. Here, we have examined the function and regulation of gastrointestinal eosinophils in the steady-state and during infection with Helicobacter pylori or Citrobacter rodentium. We find that eosinophils are recruited to sites of infection, directly encounter live bacteria, and activate a signature transcriptional program; this applies also to human gastrointestinal eosinophils in humanized mice. The genetic or anti–IL-5–mediated depletion of eosinophils results in improved control of the infection, increased inflammation, and more pronounced Th1 responses. Eosinophils control Th1 responses via the IFN-γ–dependent up-regulation of PD-L1. Furthermore, we find that the conditional loss of IFN-γR in eosinophils phenocopies the effects of eosinophil depletion. Eosinophils further possess bactericidal properties that require their degranulation and the deployment of extracellular traps. Our results highlight two novel functions of this elusive cell type and link it to gastrointestinal homeostasis and anti-bacterial defense. |
format | Online Article Text |
id | pubmed-6080907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60809072019-02-06 Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation Arnold, Isabelle C. Artola-Borán, Mariela Tallón de Lara, Paulino Kyburz, Andreas Taube, Christian Ottemann, Karen van den Broek, Maries Yousefi, Shida Simon, Hans-Uwe Müller, Anne J Exp Med Research Articles Eosinophils are predominantly known for their contribution to allergy. Here, we have examined the function and regulation of gastrointestinal eosinophils in the steady-state and during infection with Helicobacter pylori or Citrobacter rodentium. We find that eosinophils are recruited to sites of infection, directly encounter live bacteria, and activate a signature transcriptional program; this applies also to human gastrointestinal eosinophils in humanized mice. The genetic or anti–IL-5–mediated depletion of eosinophils results in improved control of the infection, increased inflammation, and more pronounced Th1 responses. Eosinophils control Th1 responses via the IFN-γ–dependent up-regulation of PD-L1. Furthermore, we find that the conditional loss of IFN-γR in eosinophils phenocopies the effects of eosinophil depletion. Eosinophils further possess bactericidal properties that require their degranulation and the deployment of extracellular traps. Our results highlight two novel functions of this elusive cell type and link it to gastrointestinal homeostasis and anti-bacterial defense. Rockefeller University Press 2018-08-06 /pmc/articles/PMC6080907/ /pubmed/29970473 http://dx.doi.org/10.1084/jem.20172049 Text en © 2018 Arnold et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Research Articles Arnold, Isabelle C. Artola-Borán, Mariela Tallón de Lara, Paulino Kyburz, Andreas Taube, Christian Ottemann, Karen van den Broek, Maries Yousefi, Shida Simon, Hans-Uwe Müller, Anne Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation |
title | Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation |
title_full | Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation |
title_fullStr | Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation |
title_full_unstemmed | Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation |
title_short | Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation |
title_sort | eosinophils suppress th1 responses and restrict bacterially induced gastrointestinal inflammation |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080907/ https://www.ncbi.nlm.nih.gov/pubmed/29970473 http://dx.doi.org/10.1084/jem.20172049 |
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