miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential

We have shown that antagomiR inhibition of miRNA miR-21 and miR-196b activity is sufficient to ablate MLL-AF9 leukemia stem cells (LSC) in vivo. Here, we used an shRNA screening approach to mimic miRNA activity on experimentally verified miR-196b targets to identify functionally important and therap...

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Detalles Bibliográficos
Autores principales: Meyer, Sara E., Muench, David E., Rogers, Andrew M., Newkold, Tess J., Orr, Emily, O’Brien, Eric, Perentesis, John P., Doench, John G., Lal, Ashish, Morris, Patrick J., Thomas, Craig J., Lieberman, Judy, McGlinn, Edwina, Aronow, Bruce J., Salomonis, Nathan, Grimes, H. Leighton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080909/
https://www.ncbi.nlm.nih.gov/pubmed/29997117
http://dx.doi.org/10.1084/jem.20171312

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