Cargando…
Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17
Macroautophagy is an evolutionarily conserved catabolic mechanism that delivers intracellular constituents to lysosomes using autophagosomes. To achieve degradation, lysosomes must fuse with closed autophagosomes. We previously reported that the soluble N-ethylmaleimide–sensitive factor attachment p...
Autores principales: | Matsui, Takahide, Jiang, Peidu, Nakano, Saori, Sakamaki, Yuriko, Yamamoto, Hayashi, Mizushima, Noboru |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080929/ https://www.ncbi.nlm.nih.gov/pubmed/29789439 http://dx.doi.org/10.1083/jcb.201712058 |
Ejemplares similares
-
The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17
por: Jiang, Peidu, et al.
Publicado: (2014) -
LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes
por: Hubert, Virginie, et al.
Publicado: (2016) -
Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion
por: Takáts, Szabolcs, et al.
Publicado: (2018) -
Ykt6 mediates autophagosome-vacuole fusion
por: Bas, Levent, et al.
Publicado: (2018) -
Reconstitution reveals Ykt6 as the autophagosomal SNARE in autophagosome–vacuole fusion
por: Bas, Levent, et al.
Publicado: (2018)