Cargando…

Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection

RATIONALE: Studies have shown that fecal microbiota transplantation (FMT) is a safe and highly efficient treatment for recurrent Clostridium difficile infection (rCDI). However, it is still unknown if one versus multiple donors or enemas versus capsule FMT are most efficient. PATIENT CONCERNS: 10 pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Chehri, Mahtab, Christensen, Alice Højer, Halkjær, Sofie Ingdam, Günther, Stig, Petersen, Andreas Munk, Helms, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081131/
https://www.ncbi.nlm.nih.gov/pubmed/30075573
http://dx.doi.org/10.1097/MD.0000000000011706
_version_ 1783345608080228352
author Chehri, Mahtab
Christensen, Alice Højer
Halkjær, Sofie Ingdam
Günther, Stig
Petersen, Andreas Munk
Helms, Morten
author_facet Chehri, Mahtab
Christensen, Alice Højer
Halkjær, Sofie Ingdam
Günther, Stig
Petersen, Andreas Munk
Helms, Morten
author_sort Chehri, Mahtab
collection PubMed
description RATIONALE: Studies have shown that fecal microbiota transplantation (FMT) is a safe and highly efficient treatment for recurrent Clostridium difficile infection (rCDI). However, it is still unknown if one versus multiple donors or enemas versus capsule FMT are most efficient. PATIENT CONCERNS: 10 patients with at least 3 previous episodes of CDI were offered treatment with FMT capsules. 9 patients decided to participate. DIAGNOSES: In this study, we treated 9 patients (25–86 years) with rCDI. INTERVENTIONS: From October to November 2016, a total of 9 patients with recurrent CDI were treated with oral fecal microbiota capsules, with mixed donor feces from 4 donors with high microbiota diversity. All patients received treatment with vancomycin prior to the capsule regime. OUTCOME: Patients had previous recurrences ranging from 2 to 10 recurrences. All 9 patients were successfully treated without recurrence after 180 days follow-up, even 2 patients previously treated with FMT enemas. LESSONS: FMT capsules based on multiple donors are highly efficient in patients with rCDI.
format Online
Article
Text
id pubmed-6081131
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-60811312018-08-17 Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection Chehri, Mahtab Christensen, Alice Højer Halkjær, Sofie Ingdam Günther, Stig Petersen, Andreas Munk Helms, Morten Medicine (Baltimore) Research Article RATIONALE: Studies have shown that fecal microbiota transplantation (FMT) is a safe and highly efficient treatment for recurrent Clostridium difficile infection (rCDI). However, it is still unknown if one versus multiple donors or enemas versus capsule FMT are most efficient. PATIENT CONCERNS: 10 patients with at least 3 previous episodes of CDI were offered treatment with FMT capsules. 9 patients decided to participate. DIAGNOSES: In this study, we treated 9 patients (25–86 years) with rCDI. INTERVENTIONS: From October to November 2016, a total of 9 patients with recurrent CDI were treated with oral fecal microbiota capsules, with mixed donor feces from 4 donors with high microbiota diversity. All patients received treatment with vancomycin prior to the capsule regime. OUTCOME: Patients had previous recurrences ranging from 2 to 10 recurrences. All 9 patients were successfully treated without recurrence after 180 days follow-up, even 2 patients previously treated with FMT enemas. LESSONS: FMT capsules based on multiple donors are highly efficient in patients with rCDI. Wolters Kluwer Health 2018-08-03 /pmc/articles/PMC6081131/ /pubmed/30075573 http://dx.doi.org/10.1097/MD.0000000000011706 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Chehri, Mahtab
Christensen, Alice Højer
Halkjær, Sofie Ingdam
Günther, Stig
Petersen, Andreas Munk
Helms, Morten
Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection
title Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection
title_full Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection
title_fullStr Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection
title_full_unstemmed Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection
title_short Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection
title_sort case series of successful treatment with fecal microbiota transplant (fmt) oral capsules mixed from multiple donors even in patients previously treated with fmt enemas for recurrent clostridium difficile infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081131/
https://www.ncbi.nlm.nih.gov/pubmed/30075573
http://dx.doi.org/10.1097/MD.0000000000011706
work_keys_str_mv AT chehrimahtab caseseriesofsuccessfultreatmentwithfecalmicrobiotatransplantfmtoralcapsulesmixedfrommultipledonorseveninpatientspreviouslytreatedwithfmtenemasforrecurrentclostridiumdifficileinfection
AT christensenalicehøjer caseseriesofsuccessfultreatmentwithfecalmicrobiotatransplantfmtoralcapsulesmixedfrommultipledonorseveninpatientspreviouslytreatedwithfmtenemasforrecurrentclostridiumdifficileinfection
AT halkjærsofieingdam caseseriesofsuccessfultreatmentwithfecalmicrobiotatransplantfmtoralcapsulesmixedfrommultipledonorseveninpatientspreviouslytreatedwithfmtenemasforrecurrentclostridiumdifficileinfection
AT guntherstig caseseriesofsuccessfultreatmentwithfecalmicrobiotatransplantfmtoralcapsulesmixedfrommultipledonorseveninpatientspreviouslytreatedwithfmtenemasforrecurrentclostridiumdifficileinfection
AT petersenandreasmunk caseseriesofsuccessfultreatmentwithfecalmicrobiotatransplantfmtoralcapsulesmixedfrommultipledonorseveninpatientspreviouslytreatedwithfmtenemasforrecurrentclostridiumdifficileinfection
AT helmsmorten caseseriesofsuccessfultreatmentwithfecalmicrobiotatransplantfmtoralcapsulesmixedfrommultipledonorseveninpatientspreviouslytreatedwithfmtenemasforrecurrentclostridiumdifficileinfection