HLA‐DQβ1 amino acid position 87 and DQB1*0301 are associated with Chinese Han SLE

BACKGROUND: Several susceptibility loci have been identified associated with Chinese Han systemic lupus erythematosus (SLE). METHODS: We carried out imputation of classical HLA alleles, amino acids and Single Nucleotide Polymorphisms (SNPs) across the MHC region in Chinese Han SLE genome‐wide associ...

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Detalles Bibliográficos
Autores principales: Sun, Jingying, Yang, Chao, Fei, Wenmin, Zhang, Xuelei, Sheng, Yujun, Zheng, Xiaodong, Tang, Huayang, Yang, Wanling, Yang, Sen, Fan, Xing, Zhang, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081216/
https://www.ncbi.nlm.nih.gov/pubmed/29676044
http://dx.doi.org/10.1002/mgg3.403
Descripción
Sumario:BACKGROUND: Several susceptibility loci have been identified associated with Chinese Han systemic lupus erythematosus (SLE). METHODS: We carried out imputation of classical HLA alleles, amino acids and Single Nucleotide Polymorphisms (SNPs) across the MHC region in Chinese Han SLE genome‐wide association study (GWAS) of mainland and Hong Kong populations for the first time using newly constructed Han‐MHC reference panel followed by stepwise conditional analysis. RESULTS: We mapped the most significant independent association to HLA‐DQβ1 at amino acid position (Phe87, p = 7.807 × 10(−17)) and an independent association at HLA‐DQB1*0301 (P (condiational) = 1.43 × 10(−7)). CONCLUSION: Our study illustrates the value of population‐specific HLA reference panel for fine‐mapping causal variants in the MHC.

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