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Alpha‐synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3ʹUTR

BACKGROUND: Multiple variants in SNCA, encoding alpha‐synuclein, a main component of Lewy bodies, are implicated in Parkinson's disease. METHODS: We searched for cis‐acting SNCA variants using allelic mRNA ratios in human brain tissues. In a SNCA 3′UTR (2,520 bp) luciferase reporter gene assay,...

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Detalles Bibliográficos
Autores principales:	Barrie, Elizabeth S., Lee, Sung‐Ha, Frater, John T., Kataki, Maria, Scharre, Douglas W., Sadee, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081226/ https://www.ncbi.nlm.nih.gov/pubmed/29730891 http://dx.doi.org/10.1002/mgg3.407

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