An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis

The hallmarks of systemic sclerosis (SSc) are autoimmunity, microangiopathy and fibrosis. Skin fibrosis is accompanied by attrition of the dermal white adipose tissue layer, and alterations in the levels and function of adiponectin. Since these findings potentially implicate adiponectin in the patho...

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Detalles Bibliográficos
Autores principales: Yamashita, Takashi, Lakota, Katja, Taniguchi, Takashi, Yoshizaki, Ayumi, Sato, Shinichi, Hong, Wen, Zhou, Xingchun, Sodin-Semrl, Snezn, Fang, Feng, Asano, Yoshihide, Varga, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081386/
https://www.ncbi.nlm.nih.gov/pubmed/30087356
http://dx.doi.org/10.1038/s41598-018-29901-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081386/
https://www.ncbi.nlm.nih.gov/pubmed/30087356
http://dx.doi.org/10.1038/s41598-018-29901-w

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