Critical role of CD4(+) T cells and IFNγ signaling in antibody-mediated resistance to Zika virus infection

Protective adaptive immunity to Zika virus (ZIKV) has been mainly attributed to cytotoxic CD8(+) T cells and neutralizing antibodies, while the participation of CD4(+) T cells in resistance has remained largely uncharacterized. Here, we show a neutralizing antibody response, dependent on CD4(+) T ce...

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Detalles Bibliográficos
Autores principales: Lucas, Carolina G. O., Kitoko, Jamil Z., Ferreira, Fabricio M., Suzart, Vinicius G., Papa, Michelle P., Coelho, Sharton V. A., Cavazzoni, Cecilia B., Paula-Neto, Heitor A., Olsen, Priscilla C., Iwasaki, Akiko, Pereira, Renata M., Pimentel-Coelho, Pedro M., Vale, Andre M., de Arruda, Luciana B., Bozza, Marcelo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081430/
https://www.ncbi.nlm.nih.gov/pubmed/30087337
http://dx.doi.org/10.1038/s41467-018-05519-4

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