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Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase

Heparan Sulfate (HS) is a cell signaling molecule linked to pathological processes ranging from cancer to viral entry, yet fundamental aspects of its biosynthesis remain incompletely understood. Here, the binding preferences of the uronyl 2-O-sulfotransferase (HS2ST) are examined with variably-sulfa...

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Detalles Bibliográficos
Autores principales:	Thieker, David F., Xu, Yongmei, Chapla, Digantkumar, Nora, Chelsea, Qiu, Hong, Felix, Thomas, Wang, Lianchun, Moremen, Kelley W., Liu, Jian, Esko, Jeffrey D., Woods, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081452/ https://www.ncbi.nlm.nih.gov/pubmed/30087361 http://dx.doi.org/10.1038/s41598-018-29602-4

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