Adaptive mutation F772S-enhanced p7-NS4A cooperation facilitates the assembly and release of hepatitis C virus and is associated with lipid droplet enlargement

Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis and liver cancer worldwide. Adaptive mutations play important roles in the development of the HCV replicon and its infectious clones. We and others have previously identified the p7 mutation F772S and the co-presence of NS4A mut...

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Detalles Bibliográficos
Autores principales: Duan, Xiaobing, Anwar, Muhammad Ikram, Xu, Zhanxue, Ma, Ling, Yuan, Guosheng, Chen, Yiyi, Liu, Xi, Xia, Jinyu, Zhou, Yuanping, Li, Yi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081454/
https://www.ncbi.nlm.nih.gov/pubmed/30087320
http://dx.doi.org/10.1038/s41426-018-0140-z

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