Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Through major histocompatibility complex class Ia leader sequence-derived (VL9) peptide binding and CD94/NKG2 receptor engagement, human leucocyte antigen E (HLA-E) reports cellular health to NK cells. Previous studies demonstrated a strong bias for VL9 binding by HLA-E, a preference subsequently su...

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Detalles Bibliográficos
Autores principales: Walters, Lucy C., Harlos, Karl, Brackenridge, Simon, Rozbesky, Daniel, Barrett, Jordan R., Jain, Vitul, Walter, Thomas S., O’Callaghan, Chris A., Borrow, Persephone, Toebes, Mireille, Hansen, Scott G., Sacha, Jonah B, Abdulhaqq, Shaheed, Greene, Justin M., Früh, Klaus, Marshall, Emily, Picker, Louis J., Jones, E. Yvonne, McMichael, Andrew J., Gillespie, Geraldine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081459/
https://www.ncbi.nlm.nih.gov/pubmed/30087334
http://dx.doi.org/10.1038/s41467-018-05459-z

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