Cargando…

Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells

Da-Cheng-Qi-Decoction (DCQD) has been used in the treatment of acute pancreatitis (AP) in China for many years. The aim of the current study was to examine the principal ingredient rhubarb of DCQD and its potential link to the pancreatic repair effects in rats with AP. The pancreatitis was induced i...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Jianlei, Li, George, Xiong, Wenbi, Liu, Litao, Xiang, Jin, Tang, Mei, Yuan, Zhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081545/
https://www.ncbi.nlm.nih.gov/pubmed/30140298
http://dx.doi.org/10.1155/2018/7321352
_version_ 1783345669791023104
author Zhao, Jianlei
Li, George
Xiong, Wenbi
Liu, Litao
Xiang, Jin
Tang, Mei
Yuan, Zhu
author_facet Zhao, Jianlei
Li, George
Xiong, Wenbi
Liu, Litao
Xiang, Jin
Tang, Mei
Yuan, Zhu
author_sort Zhao, Jianlei
collection PubMed
description Da-Cheng-Qi-Decoction (DCQD) has been used in the treatment of acute pancreatitis (AP) in China for many years. The aim of the current study was to examine the principal ingredient rhubarb of DCQD and its potential link to the pancreatic repair effects in rats with AP. The pancreatitis was induced in SD rats by intraperitoneal injections of cerulein. The results showed that rhubarb significantly increased blood perfusion of pancreatic tissue, reversed mitochondrial damage, and promoted pancreatic acinar and stellate cell proliferation. In addition, the rhein (from rhubarb) had high distribution in pancreas tissue and protected mitochondria in AR42J cells via the activation of PI3K/AKT/mTOR signaling pathway and activity inhibition of AMPK (P < 0.05). The results provide some preclinical evidence on the protective effects of DCQD for the treatment of acute pancreatitis. Rhein is regarded to be the active compound of rhubarb and can be expected to be a new compound for the treatment of AP.
format Online
Article
Text
id pubmed-6081545
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-60815452018-08-23 Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells Zhao, Jianlei Li, George Xiong, Wenbi Liu, Litao Xiang, Jin Tang, Mei Yuan, Zhu Evid Based Complement Alternat Med Research Article Da-Cheng-Qi-Decoction (DCQD) has been used in the treatment of acute pancreatitis (AP) in China for many years. The aim of the current study was to examine the principal ingredient rhubarb of DCQD and its potential link to the pancreatic repair effects in rats with AP. The pancreatitis was induced in SD rats by intraperitoneal injections of cerulein. The results showed that rhubarb significantly increased blood perfusion of pancreatic tissue, reversed mitochondrial damage, and promoted pancreatic acinar and stellate cell proliferation. In addition, the rhein (from rhubarb) had high distribution in pancreas tissue and protected mitochondria in AR42J cells via the activation of PI3K/AKT/mTOR signaling pathway and activity inhibition of AMPK (P < 0.05). The results provide some preclinical evidence on the protective effects of DCQD for the treatment of acute pancreatitis. Rhein is regarded to be the active compound of rhubarb and can be expected to be a new compound for the treatment of AP. Hindawi 2018-07-22 /pmc/articles/PMC6081545/ /pubmed/30140298 http://dx.doi.org/10.1155/2018/7321352 Text en Copyright © 2018 Jianlei Zhao et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhao, Jianlei
Li, George
Xiong, Wenbi
Liu, Litao
Xiang, Jin
Tang, Mei
Yuan, Zhu
Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells
title Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells
title_full Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells
title_fullStr Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells
title_full_unstemmed Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells
title_short Protective Effects of Rhubarb in Rats with Acute Pancreatitis and the Role of Its Active Compound Rhein on Mitochondria of Exocrine Cells
title_sort protective effects of rhubarb in rats with acute pancreatitis and the role of its active compound rhein on mitochondria of exocrine cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081545/
https://www.ncbi.nlm.nih.gov/pubmed/30140298
http://dx.doi.org/10.1155/2018/7321352
work_keys_str_mv AT zhaojianlei protectiveeffectsofrhubarbinratswithacutepancreatitisandtheroleofitsactivecompoundrheinonmitochondriaofexocrinecells
AT ligeorge protectiveeffectsofrhubarbinratswithacutepancreatitisandtheroleofitsactivecompoundrheinonmitochondriaofexocrinecells
AT xiongwenbi protectiveeffectsofrhubarbinratswithacutepancreatitisandtheroleofitsactivecompoundrheinonmitochondriaofexocrinecells
AT liulitao protectiveeffectsofrhubarbinratswithacutepancreatitisandtheroleofitsactivecompoundrheinonmitochondriaofexocrinecells
AT xiangjin protectiveeffectsofrhubarbinratswithacutepancreatitisandtheroleofitsactivecompoundrheinonmitochondriaofexocrinecells
AT tangmei protectiveeffectsofrhubarbinratswithacutepancreatitisandtheroleofitsactivecompoundrheinonmitochondriaofexocrinecells
AT yuanzhu protectiveeffectsofrhubarbinratswithacutepancreatitisandtheroleofitsactivecompoundrheinonmitochondriaofexocrinecells