Cargando…
Upregulation of the Long Noncoding RNA SNHG3 Promotes Lung Adenocarcinoma Proliferation
Lung cancer is the leading cause of cancer-associated mortalities worldwide. Non-small-cell lung cancer (NSCLC) is the main reason for cancer-relevant death and constitutes 80% of lung cancer cases. Long noncoding RNAs (lncRNAs) have been found to be related to different kinds of cancer. Long noncod...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081568/ https://www.ncbi.nlm.nih.gov/pubmed/30154938 http://dx.doi.org/10.1155/2018/5736716 |
_version_ | 1783345675263541248 |
---|---|
author | Liu, Liang Ni, Jianjiao He, Xinhong |
author_facet | Liu, Liang Ni, Jianjiao He, Xinhong |
author_sort | Liu, Liang |
collection | PubMed |
description | Lung cancer is the leading cause of cancer-associated mortalities worldwide. Non-small-cell lung cancer (NSCLC) is the main reason for cancer-relevant death and constitutes 80% of lung cancer cases. Long noncoding RNAs (lncRNAs) have been found to be related to different kinds of cancer. Long noncoding RNAs played important roles in regulating the pathological and physiological processes of numerous cancers. To explore novel lung adenocarcinoma-associated lncRNAs, we analyzed the TCGA database and found that the lncRNA SNHG3 was significantly upregulated in lung adenocarcinoma. Bioinformatic analysis showed that SNHG3 may play key roles in regulating RNA splicing, tRNA processing, signal transduction, cell adhesion, transcription, and apoptosis. We also performed functional experiments to explore the roles of SNHG3 in lung adenocarcinoma cells. We found that SNHG3 promoted proliferation, cell cycle, and suppressed cell apoptosis of lung adenocarcinoma, suggesting that SNHG3 acted as an oncogene in lung adenocarcinoma. We believe that this study will provide a potential new therapeutic and prognostic target for lung adenocarcinoma. |
format | Online Article Text |
id | pubmed-6081568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60815682018-08-28 Upregulation of the Long Noncoding RNA SNHG3 Promotes Lung Adenocarcinoma Proliferation Liu, Liang Ni, Jianjiao He, Xinhong Dis Markers Research Article Lung cancer is the leading cause of cancer-associated mortalities worldwide. Non-small-cell lung cancer (NSCLC) is the main reason for cancer-relevant death and constitutes 80% of lung cancer cases. Long noncoding RNAs (lncRNAs) have been found to be related to different kinds of cancer. Long noncoding RNAs played important roles in regulating the pathological and physiological processes of numerous cancers. To explore novel lung adenocarcinoma-associated lncRNAs, we analyzed the TCGA database and found that the lncRNA SNHG3 was significantly upregulated in lung adenocarcinoma. Bioinformatic analysis showed that SNHG3 may play key roles in regulating RNA splicing, tRNA processing, signal transduction, cell adhesion, transcription, and apoptosis. We also performed functional experiments to explore the roles of SNHG3 in lung adenocarcinoma cells. We found that SNHG3 promoted proliferation, cell cycle, and suppressed cell apoptosis of lung adenocarcinoma, suggesting that SNHG3 acted as an oncogene in lung adenocarcinoma. We believe that this study will provide a potential new therapeutic and prognostic target for lung adenocarcinoma. Hindawi 2018-07-22 /pmc/articles/PMC6081568/ /pubmed/30154938 http://dx.doi.org/10.1155/2018/5736716 Text en Copyright © 2018 Liang Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Liang Ni, Jianjiao He, Xinhong Upregulation of the Long Noncoding RNA SNHG3 Promotes Lung Adenocarcinoma Proliferation |
title | Upregulation of the Long Noncoding RNA SNHG3 Promotes Lung Adenocarcinoma Proliferation |
title_full | Upregulation of the Long Noncoding RNA SNHG3 Promotes Lung Adenocarcinoma Proliferation |
title_fullStr | Upregulation of the Long Noncoding RNA SNHG3 Promotes Lung Adenocarcinoma Proliferation |
title_full_unstemmed | Upregulation of the Long Noncoding RNA SNHG3 Promotes Lung Adenocarcinoma Proliferation |
title_short | Upregulation of the Long Noncoding RNA SNHG3 Promotes Lung Adenocarcinoma Proliferation |
title_sort | upregulation of the long noncoding rna snhg3 promotes lung adenocarcinoma proliferation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081568/ https://www.ncbi.nlm.nih.gov/pubmed/30154938 http://dx.doi.org/10.1155/2018/5736716 |
work_keys_str_mv | AT liuliang upregulationofthelongnoncodingrnasnhg3promoteslungadenocarcinomaproliferation AT nijianjiao upregulationofthelongnoncodingrnasnhg3promoteslungadenocarcinomaproliferation AT hexinhong upregulationofthelongnoncodingrnasnhg3promoteslungadenocarcinomaproliferation |