Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature

BACKGROUND: Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been link...

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Autores principales: Nakamura, Kiwamu, Saito, Kyoichi, Hara, Yasuka, Aoyagi, Tetsuji, Kitakawa, Kadzuhiro, Abe, Yoshinobu, Takemura, Hiromu, Ikeda, Fumihito, Kaku, Mitsuo, Kanemitsu, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081802/
https://www.ncbi.nlm.nih.gov/pubmed/30086720
http://dx.doi.org/10.1186/s12879-018-3284-5
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author Nakamura, Kiwamu
Saito, Kyoichi
Hara, Yasuka
Aoyagi, Tetsuji
Kitakawa, Kadzuhiro
Abe, Yoshinobu
Takemura, Hiromu
Ikeda, Fumihito
Kaku, Mitsuo
Kanemitsu, Keiji
author_facet Nakamura, Kiwamu
Saito, Kyoichi
Hara, Yasuka
Aoyagi, Tetsuji
Kitakawa, Kadzuhiro
Abe, Yoshinobu
Takemura, Hiromu
Ikeda, Fumihito
Kaku, Mitsuo
Kanemitsu, Keiji
author_sort Nakamura, Kiwamu
collection PubMed
description BACKGROUND: Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgia, regardless of the presence of underlying diseases, immunosuppression, or sex. CASE PRESENTATION: We describe an adult case of severe systemic myalgia and orchiodynia after infection with HPeV-3, which was transmitted from the child of the patient. Interleukin-6 (IL-6) level was found to be elevated in the patient’s serum. CONCLUSION: Severe myalgia associated with HPeV-3 infection is potentially caused by an elevated serum level of IL-6.
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spelling pubmed-60818022018-08-09 Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature Nakamura, Kiwamu Saito, Kyoichi Hara, Yasuka Aoyagi, Tetsuji Kitakawa, Kadzuhiro Abe, Yoshinobu Takemura, Hiromu Ikeda, Fumihito Kaku, Mitsuo Kanemitsu, Keiji BMC Infect Dis Case Report BACKGROUND: Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgia, regardless of the presence of underlying diseases, immunosuppression, or sex. CASE PRESENTATION: We describe an adult case of severe systemic myalgia and orchiodynia after infection with HPeV-3, which was transmitted from the child of the patient. Interleukin-6 (IL-6) level was found to be elevated in the patient’s serum. CONCLUSION: Severe myalgia associated with HPeV-3 infection is potentially caused by an elevated serum level of IL-6. BioMed Central 2018-08-07 /pmc/articles/PMC6081802/ /pubmed/30086720 http://dx.doi.org/10.1186/s12879-018-3284-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Nakamura, Kiwamu
Saito, Kyoichi
Hara, Yasuka
Aoyagi, Tetsuji
Kitakawa, Kadzuhiro
Abe, Yoshinobu
Takemura, Hiromu
Ikeda, Fumihito
Kaku, Mitsuo
Kanemitsu, Keiji
Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title_full Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title_fullStr Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title_full_unstemmed Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title_short Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
title_sort severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081802/
https://www.ncbi.nlm.nih.gov/pubmed/30086720
http://dx.doi.org/10.1186/s12879-018-3284-5
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