Necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis

BACKGROUND: A 56-year-old Caucasian man presented with a 2-weeks history of decreased vision in the right eye. Vitritis, papillitis, cystoid macular oedema and inferior diffuse retinal infiltration were noticed. Extensive blood work-up, anterior chamber paracentesis with polymerase chain reaction (P...

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Autores principales: Rasquin, Florence, Kisma, Nacima, Van Bol, Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081870/
https://www.ncbi.nlm.nih.gov/pubmed/30076485
http://dx.doi.org/10.1186/s12348-018-0154-7
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author Rasquin, Florence
Kisma, Nacima
Van Bol, Laure
author_facet Rasquin, Florence
Kisma, Nacima
Van Bol, Laure
author_sort Rasquin, Florence
collection PubMed
description BACKGROUND: A 56-year-old Caucasian man presented with a 2-weeks history of decreased vision in the right eye. Vitritis, papillitis, cystoid macular oedema and inferior diffuse retinal infiltration were noticed. Extensive blood work-up, anterior chamber paracentesis with polymerase chain reaction (PCR) and Goldmann-Witmer coefficient, tuberculin skin test (PPD-test), fluorodeoxyglucose Positron Emission Tomography CT scan (FDG-PET/CT), lymph node biopsy and pars plana vitrectomy were performed. RESULTS: Aqueous and vitreous samples were negative for an infectious and a lymphoproliferative etiology. Enlarged hilar and mediastinal lymph nodes were detected by FDG-PET/CT and subsequently biopsied, allowing to confirm the diagnosis of sarcoidosis. After a few months of oral corticosteroid therapy, the inflammation resolved completely and was replaced by atrophic retinal scars. CONCLUSION: Necrotising retinopathy-like lesions mimicking an infectious process or a lymphoproliferative disorder can be an atypical manifestation of ocular sarcoidosis.
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spelling pubmed-60818702018-09-11 Necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis Rasquin, Florence Kisma, Nacima Van Bol, Laure J Ophthalmic Inflamm Infect Brief Report BACKGROUND: A 56-year-old Caucasian man presented with a 2-weeks history of decreased vision in the right eye. Vitritis, papillitis, cystoid macular oedema and inferior diffuse retinal infiltration were noticed. Extensive blood work-up, anterior chamber paracentesis with polymerase chain reaction (PCR) and Goldmann-Witmer coefficient, tuberculin skin test (PPD-test), fluorodeoxyglucose Positron Emission Tomography CT scan (FDG-PET/CT), lymph node biopsy and pars plana vitrectomy were performed. RESULTS: Aqueous and vitreous samples were negative for an infectious and a lymphoproliferative etiology. Enlarged hilar and mediastinal lymph nodes were detected by FDG-PET/CT and subsequently biopsied, allowing to confirm the diagnosis of sarcoidosis. After a few months of oral corticosteroid therapy, the inflammation resolved completely and was replaced by atrophic retinal scars. CONCLUSION: Necrotising retinopathy-like lesions mimicking an infectious process or a lymphoproliferative disorder can be an atypical manifestation of ocular sarcoidosis. Springer Berlin Heidelberg 2018-08-03 /pmc/articles/PMC6081870/ /pubmed/30076485 http://dx.doi.org/10.1186/s12348-018-0154-7 Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Brief Report
Rasquin, Florence
Kisma, Nacima
Van Bol, Laure
Necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis
title Necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis
title_full Necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis
title_fullStr Necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis
title_full_unstemmed Necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis
title_short Necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis
title_sort necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081870/
https://www.ncbi.nlm.nih.gov/pubmed/30076485
http://dx.doi.org/10.1186/s12348-018-0154-7
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