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Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility

BACKGROUND: Knee osteoarthritis (KOA) is the most common form of chronic degenerative joint disease worldwide. Its incidence has increased in recent years. Aberrant expression profile of lncRNAs in damaged bone and cartilage of KOA patients has been reported recently, indicating its potential contri...

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Autores principales: Wang, Kejie, Chu, Minjie, Ding, Wenge, Jiang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081910/
https://www.ncbi.nlm.nih.gov/pubmed/30086750
http://dx.doi.org/10.1186/s12891-018-2197-1
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author Wang, Kejie
Chu, Minjie
Ding, Wenge
Jiang, Qing
author_facet Wang, Kejie
Chu, Minjie
Ding, Wenge
Jiang, Qing
author_sort Wang, Kejie
collection PubMed
description BACKGROUND: Knee osteoarthritis (KOA) is the most common form of chronic degenerative joint disease worldwide. Its incidence has increased in recent years. Aberrant expression profile of lncRNAs in damaged bone and cartilage of KOA patients has been reported recently, indicating its potential contributions in KOA development and a promising target for disease diagnosis and treatment. The aim of this study was to identify the association between genetic variation in lncRNA and KOA. METHODS: We retrieved relevant articles from the PubMed, Medline and Embase databases up to Jul 2017 investigating the association between lncRNA and the risk of osteoarthritis. There are 15 lncRNAs which show connection with osteoarthritis. We selected potential functional polymorphisms identified by RegulomeDB database in these lncRNAs. A case-control study was conducted which contained 278 KOA patients and 289 OA-free controls. RESULTS: Logistic regression analyses revealed that H19 rs2067051 T allele was significantly associated with decreased risk of KOA after adjusted for age, gender and BMI in recessive genetic model (OR = 0.63, P = 0.03) and additive genetic model (OR = 0.79, P = 0.03). MEG3 rs4378559 T allele was significantly associated with increased risk of KOA in additive genetic model (OR = 1.32, P = 0.04). Heterogeneity tests proved that H19 rs2067051, MEG3 rs4378559 and HOTTIP rs202384’s risk effects on KOA were more remarkable for female, BMI ≥ 25 and younger age (age < 60), respectively. CONCLUSION: The results indicate that potential functional genetic variation in lncRNA plays an important role in the pathogenesis of KOA.
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spelling pubmed-60819102018-08-10 Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility Wang, Kejie Chu, Minjie Ding, Wenge Jiang, Qing BMC Musculoskelet Disord Research Article BACKGROUND: Knee osteoarthritis (KOA) is the most common form of chronic degenerative joint disease worldwide. Its incidence has increased in recent years. Aberrant expression profile of lncRNAs in damaged bone and cartilage of KOA patients has been reported recently, indicating its potential contributions in KOA development and a promising target for disease diagnosis and treatment. The aim of this study was to identify the association between genetic variation in lncRNA and KOA. METHODS: We retrieved relevant articles from the PubMed, Medline and Embase databases up to Jul 2017 investigating the association between lncRNA and the risk of osteoarthritis. There are 15 lncRNAs which show connection with osteoarthritis. We selected potential functional polymorphisms identified by RegulomeDB database in these lncRNAs. A case-control study was conducted which contained 278 KOA patients and 289 OA-free controls. RESULTS: Logistic regression analyses revealed that H19 rs2067051 T allele was significantly associated with decreased risk of KOA after adjusted for age, gender and BMI in recessive genetic model (OR = 0.63, P = 0.03) and additive genetic model (OR = 0.79, P = 0.03). MEG3 rs4378559 T allele was significantly associated with increased risk of KOA in additive genetic model (OR = 1.32, P = 0.04). Heterogeneity tests proved that H19 rs2067051, MEG3 rs4378559 and HOTTIP rs202384’s risk effects on KOA were more remarkable for female, BMI ≥ 25 and younger age (age < 60), respectively. CONCLUSION: The results indicate that potential functional genetic variation in lncRNA plays an important role in the pathogenesis of KOA. BioMed Central 2018-08-07 /pmc/articles/PMC6081910/ /pubmed/30086750 http://dx.doi.org/10.1186/s12891-018-2197-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wang, Kejie
Chu, Minjie
Ding, Wenge
Jiang, Qing
Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility
title Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility
title_full Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility
title_fullStr Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility
title_full_unstemmed Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility
title_short Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility
title_sort putative functional variants of lncrna identified by regulomedb were associated with knee osteoarthritis susceptibility
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081910/
https://www.ncbi.nlm.nih.gov/pubmed/30086750
http://dx.doi.org/10.1186/s12891-018-2197-1
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