PCBP1 depletion promotes tumorigenesis through attenuation of p27(Kip1) mRNA stability and translation

BACKGROUND: Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis remains elusive. METHODS: We performed a transcri...

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Detalles Bibliográficos
Autores principales: Shi, Hongshun, Li, Hui, Yuan, Ronghua, Guan, Wen, Zhang, Xiaomei, Zhang, Shaoyang, Zhang, Wenliang, Tong, Fang, Li, Li, Song, Zhihong, Wang, Changwei, Yang, Shulan, Wang, Haihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081911/
https://www.ncbi.nlm.nih.gov/pubmed/30086790
http://dx.doi.org/10.1186/s13046-018-0840-1

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