Cargando…

Progress towards Bait Station Integration into Oral Rabies Vaccination Programs in the United States: Field Trials in Massachusetts and Florida

Bait stations for distribution of oral rabies vaccine baits are designed for rabies management in highly-developed areas where traditional distribution of oral rabies vaccine baits may be difficult. As part of national efforts to contain and eliminate the raccoon (Procyon lotor) variant of the rabie...

Descripción completa

Detalles Bibliográficos
Autores principales: Bjorklund, Brian M., Haley, Betsy S., Bevilacqua, Ryan J., Chandler, Monte D., Duffiney, Anthony G., von Hone, Karl W., Slate, Dennis, Chipman, Richard B., Martin, Ashlee, Algeo, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082100/
https://www.ncbi.nlm.nih.gov/pubmed/30270897
http://dx.doi.org/10.3390/tropicalmed2030040
_version_ 1783345764812980224
author Bjorklund, Brian M.
Haley, Betsy S.
Bevilacqua, Ryan J.
Chandler, Monte D.
Duffiney, Anthony G.
von Hone, Karl W.
Slate, Dennis
Chipman, Richard B.
Martin, Ashlee
Algeo, Timothy P.
author_facet Bjorklund, Brian M.
Haley, Betsy S.
Bevilacqua, Ryan J.
Chandler, Monte D.
Duffiney, Anthony G.
von Hone, Karl W.
Slate, Dennis
Chipman, Richard B.
Martin, Ashlee
Algeo, Timothy P.
author_sort Bjorklund, Brian M.
collection PubMed
description Bait stations for distribution of oral rabies vaccine baits are designed for rabies management in highly-developed areas where traditional distribution of oral rabies vaccine baits may be difficult. As part of national efforts to contain and eliminate the raccoon (Procyon lotor) variant of the rabies virus (raccoon rabies) in the eastern United States, the United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services program, distributed vaccine baits by bait stations experimentally and operationally in Massachusetts during 2006-present, and in Florida during 2009–2015. In Massachusetts, a rabies virus-neutralizing antibody (RVNA) response of 42.1% for raccoons captured in areas baited with high density bait stations during 2011–2015 was achieved, compared with 46.2% in areas baited by hand, suggesting the continuation of this as a strategy for the oral rabies vaccination (ORV) program there, and for similar locations. Non-target competition for vaccine baits is problematic, regardless of distribution method. In Massachusetts, bait station visitation rates for targeted raccoons and non-target opossums (Didelphis virginiana) were similar (1.18:1) during 2006–2009 (p > 0.05). Bait station modifications for reducing non-target uptake were tested, and in Massachusetts, reduced non-target bait access was achieved with two design alternatives (p < 0.001). However, no difference was noted between the control and these two alternative designs in Florida. Due to ongoing trials of new vaccines and baits, the bait station performance of an adenovirus rabies glycoprotein recombinant vaccine bait, ONRAB(®) bait (Artemis Technologies, Guelph, ON, Canada) and a vaccinia-rabies glycoprotein recombinant vaccine bait, RABORAL V-RG(®)bait (Merial Limited, Athens, GA, USA), was compared. While uptake of the ONRAB bait was greater in Massachusetts (p < 0.001) in this limited trial, both types performed equally well in Florida. Since bait station tampering or theft as well as potential human bait contacts has been problematic, performance of camouflaged versus unpainted white bait stations was analyzed in terms of internal temperatures and maintaining a stable bait storage environment. In Massachusetts, camouflaged bait station interiors did not reach higher average temperatures than plain white bait stations in partially- or fully-shaded locations, while in Florida, camouflaged bait stations were significantly warmer in light exposure categories (p < 0.05). As ORV operations expand into more heavily-urbanized areas, bait stations will be increasingly important for vaccine bait distribution, and continued refinements in the strategy will be key to that success.
format Online
Article
Text
id pubmed-6082100
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60821002018-09-24 Progress towards Bait Station Integration into Oral Rabies Vaccination Programs in the United States: Field Trials in Massachusetts and Florida Bjorklund, Brian M. Haley, Betsy S. Bevilacqua, Ryan J. Chandler, Monte D. Duffiney, Anthony G. von Hone, Karl W. Slate, Dennis Chipman, Richard B. Martin, Ashlee Algeo, Timothy P. Trop Med Infect Dis Article Bait stations for distribution of oral rabies vaccine baits are designed for rabies management in highly-developed areas where traditional distribution of oral rabies vaccine baits may be difficult. As part of national efforts to contain and eliminate the raccoon (Procyon lotor) variant of the rabies virus (raccoon rabies) in the eastern United States, the United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services program, distributed vaccine baits by bait stations experimentally and operationally in Massachusetts during 2006-present, and in Florida during 2009–2015. In Massachusetts, a rabies virus-neutralizing antibody (RVNA) response of 42.1% for raccoons captured in areas baited with high density bait stations during 2011–2015 was achieved, compared with 46.2% in areas baited by hand, suggesting the continuation of this as a strategy for the oral rabies vaccination (ORV) program there, and for similar locations. Non-target competition for vaccine baits is problematic, regardless of distribution method. In Massachusetts, bait station visitation rates for targeted raccoons and non-target opossums (Didelphis virginiana) were similar (1.18:1) during 2006–2009 (p > 0.05). Bait station modifications for reducing non-target uptake were tested, and in Massachusetts, reduced non-target bait access was achieved with two design alternatives (p < 0.001). However, no difference was noted between the control and these two alternative designs in Florida. Due to ongoing trials of new vaccines and baits, the bait station performance of an adenovirus rabies glycoprotein recombinant vaccine bait, ONRAB(®) bait (Artemis Technologies, Guelph, ON, Canada) and a vaccinia-rabies glycoprotein recombinant vaccine bait, RABORAL V-RG(®)bait (Merial Limited, Athens, GA, USA), was compared. While uptake of the ONRAB bait was greater in Massachusetts (p < 0.001) in this limited trial, both types performed equally well in Florida. Since bait station tampering or theft as well as potential human bait contacts has been problematic, performance of camouflaged versus unpainted white bait stations was analyzed in terms of internal temperatures and maintaining a stable bait storage environment. In Massachusetts, camouflaged bait station interiors did not reach higher average temperatures than plain white bait stations in partially- or fully-shaded locations, while in Florida, camouflaged bait stations were significantly warmer in light exposure categories (p < 0.05). As ORV operations expand into more heavily-urbanized areas, bait stations will be increasingly important for vaccine bait distribution, and continued refinements in the strategy will be key to that success. MDPI 2017-08-21 /pmc/articles/PMC6082100/ /pubmed/30270897 http://dx.doi.org/10.3390/tropicalmed2030040 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bjorklund, Brian M.
Haley, Betsy S.
Bevilacqua, Ryan J.
Chandler, Monte D.
Duffiney, Anthony G.
von Hone, Karl W.
Slate, Dennis
Chipman, Richard B.
Martin, Ashlee
Algeo, Timothy P.
Progress towards Bait Station Integration into Oral Rabies Vaccination Programs in the United States: Field Trials in Massachusetts and Florida
title Progress towards Bait Station Integration into Oral Rabies Vaccination Programs in the United States: Field Trials in Massachusetts and Florida
title_full Progress towards Bait Station Integration into Oral Rabies Vaccination Programs in the United States: Field Trials in Massachusetts and Florida
title_fullStr Progress towards Bait Station Integration into Oral Rabies Vaccination Programs in the United States: Field Trials in Massachusetts and Florida
title_full_unstemmed Progress towards Bait Station Integration into Oral Rabies Vaccination Programs in the United States: Field Trials in Massachusetts and Florida
title_short Progress towards Bait Station Integration into Oral Rabies Vaccination Programs in the United States: Field Trials in Massachusetts and Florida
title_sort progress towards bait station integration into oral rabies vaccination programs in the united states: field trials in massachusetts and florida
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082100/
https://www.ncbi.nlm.nih.gov/pubmed/30270897
http://dx.doi.org/10.3390/tropicalmed2030040
work_keys_str_mv AT bjorklundbrianm progresstowardsbaitstationintegrationintooralrabiesvaccinationprogramsintheunitedstatesfieldtrialsinmassachusettsandflorida
AT haleybetsys progresstowardsbaitstationintegrationintooralrabiesvaccinationprogramsintheunitedstatesfieldtrialsinmassachusettsandflorida
AT bevilacquaryanj progresstowardsbaitstationintegrationintooralrabiesvaccinationprogramsintheunitedstatesfieldtrialsinmassachusettsandflorida
AT chandlermonted progresstowardsbaitstationintegrationintooralrabiesvaccinationprogramsintheunitedstatesfieldtrialsinmassachusettsandflorida
AT duffineyanthonyg progresstowardsbaitstationintegrationintooralrabiesvaccinationprogramsintheunitedstatesfieldtrialsinmassachusettsandflorida
AT vonhonekarlw progresstowardsbaitstationintegrationintooralrabiesvaccinationprogramsintheunitedstatesfieldtrialsinmassachusettsandflorida
AT slatedennis progresstowardsbaitstationintegrationintooralrabiesvaccinationprogramsintheunitedstatesfieldtrialsinmassachusettsandflorida
AT chipmanrichardb progresstowardsbaitstationintegrationintooralrabiesvaccinationprogramsintheunitedstatesfieldtrialsinmassachusettsandflorida
AT martinashlee progresstowardsbaitstationintegrationintooralrabiesvaccinationprogramsintheunitedstatesfieldtrialsinmassachusettsandflorida
AT algeotimothyp progresstowardsbaitstationintegrationintooralrabiesvaccinationprogramsintheunitedstatesfieldtrialsinmassachusettsandflorida