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Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines

Over five years, a total of 646 P. aeruginosa isolates was acquired from different clinical specimens and their resistance to the commonly used anti-pseudomonal antibiotics was determined. The majority of the isolates were from respiratory (60.99%) and urinary sources (23.22%) while the least came f...

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Autores principales: Juayang, Alain C., Lim, Joseph Peter T., Bonifacio, Ann Francis V., Lambot, Alaica Victoria L., Millan, Sean Maybelle, Sevilla, Vic Zyrus Jeriko N., Sy, Julien Kate T., Villanueva, Paul John, Grajales, Carmina P., Gallega, Christine T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082103/
https://www.ncbi.nlm.nih.gov/pubmed/30270886
http://dx.doi.org/10.3390/tropicalmed2030028
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author Juayang, Alain C.
Lim, Joseph Peter T.
Bonifacio, Ann Francis V.
Lambot, Alaica Victoria L.
Millan, Sean Maybelle
Sevilla, Vic Zyrus Jeriko N.
Sy, Julien Kate T.
Villanueva, Paul John
Grajales, Carmina P.
Gallega, Christine T.
author_facet Juayang, Alain C.
Lim, Joseph Peter T.
Bonifacio, Ann Francis V.
Lambot, Alaica Victoria L.
Millan, Sean Maybelle
Sevilla, Vic Zyrus Jeriko N.
Sy, Julien Kate T.
Villanueva, Paul John
Grajales, Carmina P.
Gallega, Christine T.
author_sort Juayang, Alain C.
collection PubMed
description Over five years, a total of 646 P. aeruginosa isolates was acquired from different clinical specimens and their resistance to the commonly used anti-pseudomonal antibiotics was determined. The majority of the isolates were from respiratory (60.99%) and urinary sources (23.22%) while the least came from transudates and exudates (2.01%). Most of the samples were acquired from older adults (77.55%), most of whom were admitted (67.03%). Amikacin was found to be the most effective drug with a resistance rate of 7.5%, followed by piperacillin/tazobactam (8.5%) and gentamicin (13.5%). On the other hand, 26.7% of the isolates were resistant to levofloxacin. Almost 100% of the isolates were screened positive for AmpC production, which may suggest inducible resistance against expanded spectrum beta-lactamase. Furthermore, for the last three years, P. aeruginosa isolates from this area have been noted to have decreasing resistance only to aztreonam and gentamicin. Also, for five years, a mean MAR index of 0.17 was noted which indicates either proper antibiotic use or most isolates did not come from high-risk areas. Moreover, there was no significant difference in the resistance of P. aeruginosa when compared by specimen source (p = 0.662), but significant when compared by year band (p = 0.02).
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spelling pubmed-60821032018-09-24 Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines Juayang, Alain C. Lim, Joseph Peter T. Bonifacio, Ann Francis V. Lambot, Alaica Victoria L. Millan, Sean Maybelle Sevilla, Vic Zyrus Jeriko N. Sy, Julien Kate T. Villanueva, Paul John Grajales, Carmina P. Gallega, Christine T. Trop Med Infect Dis Article Over five years, a total of 646 P. aeruginosa isolates was acquired from different clinical specimens and their resistance to the commonly used anti-pseudomonal antibiotics was determined. The majority of the isolates were from respiratory (60.99%) and urinary sources (23.22%) while the least came from transudates and exudates (2.01%). Most of the samples were acquired from older adults (77.55%), most of whom were admitted (67.03%). Amikacin was found to be the most effective drug with a resistance rate of 7.5%, followed by piperacillin/tazobactam (8.5%) and gentamicin (13.5%). On the other hand, 26.7% of the isolates were resistant to levofloxacin. Almost 100% of the isolates were screened positive for AmpC production, which may suggest inducible resistance against expanded spectrum beta-lactamase. Furthermore, for the last three years, P. aeruginosa isolates from this area have been noted to have decreasing resistance only to aztreonam and gentamicin. Also, for five years, a mean MAR index of 0.17 was noted which indicates either proper antibiotic use or most isolates did not come from high-risk areas. Moreover, there was no significant difference in the resistance of P. aeruginosa when compared by specimen source (p = 0.662), but significant when compared by year band (p = 0.02). MDPI 2017-07-12 /pmc/articles/PMC6082103/ /pubmed/30270886 http://dx.doi.org/10.3390/tropicalmed2030028 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Juayang, Alain C.
Lim, Joseph Peter T.
Bonifacio, Ann Francis V.
Lambot, Alaica Victoria L.
Millan, Sean Maybelle
Sevilla, Vic Zyrus Jeriko N.
Sy, Julien Kate T.
Villanueva, Paul John
Grajales, Carmina P.
Gallega, Christine T.
Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines
title Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines
title_full Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines
title_fullStr Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines
title_full_unstemmed Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines
title_short Five-Year Antimicrobial Susceptibility of Pseudomonas aeruginosa from a Local Tertiary Hospital in Bacolod City, Philippines
title_sort five-year antimicrobial susceptibility of pseudomonas aeruginosa from a local tertiary hospital in bacolod city, philippines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082103/
https://www.ncbi.nlm.nih.gov/pubmed/30270886
http://dx.doi.org/10.3390/tropicalmed2030028
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